Exposure to negative socio-emotional events induces sustained alteration of resting-state brain networks in older adults

Article Article scientifique Article Exposure to negative socio-emotional events induces sustained alteration of resting-state brain networks in older adults eng 2023-01-12 2023-01-12 author Baez Lugo Sebastian 0000-0002-7781-2387 700953 author Deza Yacila 0000-0002-2624-077X 925961 author Maradan Christel 808933 author Collette Fabienne 0000-0001-9288-9756 author Lutz Antoine author Marchant Natalie L. 0000-0003-0669-6910 author Chételat Gaël 0000-0002-4889-7932 author Vuilleumier Patrik 0000-0002-8198-9214 134853 Département de neurosciences fondamentales (NEUFO) author Klimecki-Lenz Olga Maria 0000-0003-0757-7761 797242 Medit-Ageing Research Group author Arenaza-Urquijo Eider author André Claire author Botton Maelle author Cantou Pauline author Chételat Gaëlle author Chocat Anne author De la Sayette Vincent author Delarue Marion author Egret Stéphanie author Ferrand Devouge Eglantine author Frison Eric author Gonneaud Julie author Heidmann Marc author Kuhn Elizabeth author Landeau Brigitte author Le Du Gwendoline author Lefranc Valérie author Mezenge Florence author Moulinet Inès author Ourry Valentin author Poisnel Géraldine author Quillard Anne author Rauchs Géraldine author Rehel Stéphane author Tomadesso Clémence author Touron Edelweiss author Ware Caitlin author Wirth Miranka 105-120 10.1038/s43587-022-00341-6 37118519 2662-8465 https://www.nature.com/articles/s43587-022-00341-6 Basic emotional functions seem well preserved in older adults. However, their reactivity to and recovery from socially negative events remain poorly characterized. To address this, we designed a 'task-rest' paradigm in which 182 participants from two independent experiments underwent functional magnetic resonance imaging while exposed to socio-emotional videos. Experiment 1 (N = 55) validated the task in young and older participants and unveiled age-dependent effects on brain activity and connectivity that predominated in resting periods after (rather than during) negative social scenes. Crucially, emotional elicitation potentiated subsequent resting-state connectivity between default mode network and amygdala exclusively in older adults. Experiment 2 replicated these results in a large older adult cohort (N = 127) and additionally showed that emotion-driven changes in posterior default mode network-amygdala connectivity were associated with anxiety, rumination and negative thoughts. These findings uncover the neural dynamics of empathy-related functions in older adults and help understand its relationship to poor social stress recovery. Aged Amygdala / diagnostic imaging Brain Mapping Brain / diagnostic imaging Emotions Humans Magnetic Resonance Imaging Dewey 128.37 Dewey 616.8 European Commission Investigating the impact of meditation training on mental health and wellbeing in the ageing population 667696 MEDIT-AGEING EU H2020 15 Centre interfacultaire en sciences affectives 0D8 53 Département de neurosciences fondamentales 21A false 1241 Affective sciences 428 Mécanismes cérébraux du comportement et des fonctions cognitives 701 Nature aging 3 1 7565375b-f87b-4551-a3f6-be063ef26e98 Article (Published version) Restricted Article-scientifique-from-crossref.pdf 6560690 application/pdf 499bbc76e951d8e37fa833feed0f8fb0e21d3237590c2ad87ede85ce502b1170 cca0ce2a-1e6a-459b-873d-27120102315e Article (Accepted version) Public Manuscript_postprintauthor_ BaezLug.pdf 5040786 application/pdf Restricted 2023-07-13 831f01f5d8dc99eafb7eec0c7f08e32f72c309e860c44f7b9db314d835852291 11eb016f-163a-4fe5-a784-a5821bac5850 Supplemental data Public 43587_2022_341_MOESM1_ESM.pdf 1804472 application/pdf 06da10a0f3b94de4fc697012e07213355d13b6e275c33a88ea16240552ad4c73 openAccess Centres et instituts / Centre interfacultaire en sciences affectives Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

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Exposure to negative socio-emotional events induces sustained alteration of resting-state brain networks in older adults	Nature aging			2023	258	141

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