Scientific article
Open access

Frequency of Abnormally Low Neuropsychological Scores in Post-COVID-19 Syndrome: the Geneva COVID-COG Cohort

Published inArchives of clinical neuropsychology, vol. 38, no. 1, acac068
Publication date2023-02
First online date2022-08-09

Objective: Several studies have reported poor long-term neuropsychological performances in patients following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but none has yet considered the effect of administering multiple intercorrelated neuropsychological tests and assessed the frequency of cognitive deficits in a normative population. Our aim was therefore to assess the presence of cumulative neuropsychological deficits in an actual post-coronavirus disease of 2019 (COVID-19) comparison group versus one simulated using Monte-Carlo methods.

Method: Validated neuropsychological Monte-Carlo simulation methods were applied to scores from a battery of neuropsychological tests (memory, executive, attentional, perceptual, logical reasoning, language, and ideomotor praxis) administered to 121 patients who had had mild, moderate, or severe COVID-19 (mean age: 56.70 years; 32% women), 222 ± 43 days post-infection. The cumulative percentages of the three severity subgroups were compared with the results of a false discovery rate-corrected probability analysis based on normative data.

Results: The cumulative percentages of deficits in memory and executive functions among the severe and moderate patients were significantly higher than those estimated for the normative population. Moderate patients also had significantly more deficits in perception and logical reasoning. In contrast, the mild group did not have significantly more cumulative deficits.

Conclusions: Moderate and severe forms of COVID-19 cause greater long-term neuropsychological deficits than those that would be found in a normative population, reinforcing the hypothesis of long-term effects of SARS-CoV-2 on cognitive function, independent of the severity of the initial infection.

  • Executive functions
  • Memory
  • Neuropsychology
  • Post-COVID-19 condition
  • Simulation
  • COVID-19 / complications
  • Cognition Disorders / etiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Post-Acute COVID-19 Syndrome
  • SARS-CoV-2
Citation (ISO format)
VORUZ, Philippe et al. Frequency of Abnormally Low Neuropsychological Scores in Post-COVID-19 Syndrome: the Geneva COVID-COG Cohort. In: Archives of clinical neuropsychology, 2023, vol. 38, n° 1, p. acac068. doi: 10.1093/arclin/acac068
Main files (1)
Article (Published version)
Secondary files (1)
ISSN of the journal0887-6177

Technical informations

Creation09/05/2022 10:51:00 AM
First validation09/05/2022 10:51:00 AM
Update time06/30/2023 10:25:27 AM
Status update06/30/2023 10:25:27 AM
Last indexation05/06/2024 3:20:23 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack