en
Scientific article
Open access
English

The 18 kDa translocator protein is associated with microglia in the hippocampus of non-demented elderly subjects

Published inAging brain, vol. 2, 100045
Publication date2022-07-08
First online date2022-07-08
Abstract

Increase in the brain expression of the 18 kDa translocator protein (TSPO) is considered as a marker of neuroinflammation in the context of brain diseases, such as Alzheimer’s disease (AD). However, in non-demented subjects with Alzheimer’s neuropathology, TSPO accumulation in hippocampus subdivisions has not been fully characterized.

To determine if TSPO is associated with the presence of amyloid β plaques and/or phosphorylated Tau accumulation, we analyzed hippocampal sections using immunohistochemistry of 14 non-demented subjects with positive staining for Aβ and/or phosphorylated Tau. TSPO expression was heterogenous with higher accumulation in the CA2/3 and subiculum subfields of the hippocampus. Its distribution closely resembled that of the microglial IBA1 marker and of the Aβ42 amyloid form. In addition, positive correlations were observed between TSPO and IBA1 densities in CA4, CA2/3 and the subiculum but not with either the astrocyte GFAP marker or the AD-type Aβ and Tau markers. This study sustains the hypothesis that TSPO is mainly associated with microglia and in Aβ42-rich subdivisions in the hippocampus of non-demented elderly individuals.

eng
Keywords
  • TSPO
  • Alzheimer’s disease
  • Neuropathology
  • Non-demented
Funding
  • Velux foundation - [1123]
Citation (ISO format)
TOURNIER, Benjamin et al. The 18 kDa translocator protein is associated with microglia in the hippocampus of non-demented elderly subjects. In: Aging brain, 2022, vol. 2, p. 100045. doi: 10.1016/j.nbas.2022.100045
Main files (1)
Article (Published version)
Secondary files (1)
Identifiers
ISSN of the journal2589-9589
95views
53downloads

Technical informations

Creation07/13/2022 7:41:00 AM
First validation07/13/2022 7:41:00 AM
Update time03/16/2023 8:55:21 AM
Status update03/16/2023 8:55:20 AM
Last indexation05/06/2024 12:01:15 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack