The 18 kDa translocator protein is associated with microglia in the hippocampus of non-demented elderly subjects

Article Article scientifique Article The 18 kDa translocator protein is associated with microglia in the hippocampus of non-demented elderly subjects eng 2022-07-08 2022-07-08 author Tournier Benjamin 0000-0002-8027-7530 705309 author Snoeijs Christophe Raymond Jean 855727 author Tsartsalis Stergios 0000-0002-6565-6313 782369 author Amosse Quentin 0000-0002-5553-9594 934939 author Farchoukh Ramzi 907338 author Kovari Eniko Veronika 501395 author Ceyzeriat Kelly 910236 author Millet Philippe 0000-0002-5803-0478 668343 100045 10.1016/j.nbas.2022.100045 2589-9589 https://linkinghub.elsevier.com/retrieve/pii/S2589958922000172 <p>Increase in the brain expression of the 18 kDa translocator protein (TSPO) is considered as a marker of neuroinflammation in the context of brain diseases, such as Alzheimer’s disease (AD). However, in non-demented subjects with Alzheimer’s neuropathology, TSPO accumulation in hippocampus subdivisions has not been fully characterized.</p> <p>To determine if TSPO is associated with the presence of amyloid β plaques and/or phosphorylated Tau accumulation, we analyzed hippocampal sections using immunohistochemistry of 14 non-demented subjects with positive staining for Aβ and/or phosphorylated Tau. TSPO expression was heterogenous with higher accumulation in the CA2/3 and subiculum subfields of the hippocampus. Its distribution closely resembled that of the microglial IBA1 marker and of the Aβ42 amyloid form. In addition, positive correlations were observed between TSPO and IBA1 densities in CA4, CA2/3 and the subiculum but not with either the astrocyte GFAP marker or the AD-type Aβ and Tau markers. This study sustains the hypothesis that TSPO is mainly associated with microglia and in Aβ42-rich subdivisions in the hippocampus of non-demented elderly individuals.</p> TSPO Alzheimer’s disease Neuropathology Non-demented Dewey 616.89 Dewey 616.0757 Velux foundation 1123 60 Département de psychiatrie 225 62 Département de radiologie et informatique médicale 227 false 1221 Neuroimagerie moléculaire en psychiatrie 983 Aging brain 2 f203b695-980b-4c7a-b464-4796ed989d14 Article (Published version) Public 1-s2.0-S2589958922000172-main.pdf 2715102 application/pdf CC BY-NC-4.0 22cc1abc-231f-4c1b-8240-3286909bada7 Supplemental data Public 1-s2.0-S2589958922000172-mmc1.docx 16930 application/vnd.openxmlformats-officedocument.wordprocessingml.document Clinical data of the subjects. Vignette Public 1-s2.0-S2589958922000172-ga1_lrg.jpg 119725 image/jpeg openAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

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The 18 kDa translocator protein is associated with microglia in the hippocampus of non-demented elderly subjects	Aging brain			2022	185	160

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Snoeijs, Christophe Raymond Jean