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Scientific article
English

Electronic monitoring of potential adverse drug events related to lopinavir/ritonavir and hydroxychloroquine during the first wave of COVID-19

First online date2021-04-08
Abstract

During Switzerland's first wave of COVID-19, clinical pharmacy activities during medical rounds in Geneva University Hospitals were replaced by targeted remote interventions. We describe using the electronic PharmaCheck system to screen high-risk situations of adverse drug events (ADEs), particularly targeting prescriptions of lopinavir/ritonavir (LPVr) and hydroxychloroquine (HCQ) in the presence of contraindications or prescriptions outside institutional guidelines. Of 416 patients receiving LPVr and/or HCQ, 182 alerts were triggered for 164 (39.4%) patients. The main associated risk factors of ADEs were drug-drug interactions, QTc interval prolongation, electrolyte disorder and inadequate LPVr dosage. Therapeutic optimisation recommended by a pharmacist or proposals for additional monitoring were accepted in 80% (n=36) of cases. Combined with pharmacist contextualisation to the clinical context, PharmaCheck made it possible to successfully adapt clinical pharmacist activities by switching from a global to a targeted analysis mode in an emergency context.

eng
Keywords
  • COVID-19
  • Automation
  • Drug-related side effects and adverse reactions
  • Hospital
  • Medical informatics
  • Pharmacy service
Citation (ISO format)
SKALAFOURIS, Christian et al. Electronic monitoring of potential adverse drug events related to lopinavir/ritonavir and hydroxychloroquine during the first wave of COVID-19. In: European journal of hospital pharmacy, 2021. doi: 10.1136/ejhpharm-2020-002667
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Article (Published version)
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Identifiers
ISSN of the journal2047-9956
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Technical informations

Creation02/22/2022 3:22:00 PM
First validation02/22/2022 3:22:00 PM
Update time03/16/2023 6:30:34 AM
Status update03/16/2023 6:30:33 AM
Last indexation08/31/2023 8:23:34 AM
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