Currently, the vaccination coverage in Switzerland is around 68.5% of the total population, lagging behind most of its neighbouring countries (e.g., France, Germany, and Italy). By addressing vaccine hesitancy, in addition to setting up non-pharmacological measures and interventions, many countries were more or less successful in alleviating the fifth wave of the COVID-19 pandemic. Scientists suggested that SARS-CoV-2 – the virus that causes COVID-19 – would mutate with time and that vaccination is the key element to fight such variants. Our reports are the outcome of daily COVID-19 vaccine-related literature screenings. This short report addresses the most relevant data on COVID-19 vaccines literature as of 16 December 2021. The current report addresses the latest data on the newly identified variant of concern (VOC) Omicron, vaccine duration of protection, breakthrough infections, and vaccine booster doses.