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Title

Loss of direct adrenergic innervation after peripheral nerve injury causes lymph node expansion through IFN-γ

Authors
Chen, Chien-Sin
Weber, Jasmin
Holtkamp, Stephan Jonas
de Juan, Alba
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Published in The Journal of experimental medicine. 2021, vol. 218, no. 8, e20202377
Abstract Peripheral nerve injury can cause debilitating disease and immune cell-mediated destruction of the affected nerve. While the focus has been on the nerve-regenerative response, the effect of loss of innervation on lymph node function is unclear. Here, we show that the popliteal lymph node (popLN) receives direct neural input from the sciatic nerve and that sciatic denervation causes lymph node expansion. Loss of sympathetic, adrenergic tone induces the expression of IFN-γ in LN CD8 T cells, which is responsible for LN expansion. Surgery-induced IFN-γ expression and expansion can be rescued by β2 adrenergic receptor agonists but not sensory nerve agonists. These data demonstrate the mechanisms governing the pro-inflammatory effect of loss of direct adrenergic input on lymph node function.
Keywords Adrenergic Agents / metabolismAnimalsAntigens / immunologyAutoimmunityAxotomyCD8-Positive T-Lymphocytes / immunologyDenervationInflammation / pathologyInterferon-gamma / metabolismLymph Nodes / pathologyMaleMice, Inbred C57BLPeripheral Nerve Injuries / pathologySciatic Nerve / immunologySciatic Nerve / pathologySignal Transduction
Identifiers
PMID: 34086056
PMCID: PMC8185988
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Structures
Research group L'influence du rôle du cycle circadien sur l'immunité (995)
Project
European Commission: CIRCODE
Citation
(ISO format)
CHEN, Chien-Sin et al. Loss of direct adrenergic innervation after peripheral nerve injury causes lymph node expansion through IFN-γ. In: The journal of experimental medicine , 2021, vol. 218, n° 8, p. e20202377. doi: 10.1084/jem.20202377 https://archive-ouverte.unige.ch/unige:156520

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Deposited on : 2021-11-18

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