Scientific article
Open access

Loss of direct adrenergic innervation after peripheral nerve injury causes lymph node expansion through IFN-γ

Published inThe journal of experimental medicine, vol. 218, no. 8, e20202377
Publication date2021-08-02
First online date2021-06-04

Peripheral nerve injury can cause debilitating disease and immune cell-mediated destruction of the affected nerve. While the focus has been on the nerve-regenerative response, the effect of loss of innervation on lymph node function is unclear. Here, we show that the popliteal lymph node (popLN) receives direct neural input from the sciatic nerve and that sciatic denervation causes lymph node expansion. Loss of sympathetic, adrenergic tone induces the expression of IFN-γ in LN CD8 T cells, which is responsible for LN expansion. Surgery-induced IFN-γ expression and expansion can be rescued by β2 adrenergic receptor agonists but not sensory nerve agonists. These data demonstrate the mechanisms governing the pro-inflammatory effect of loss of direct adrenergic input on lymph node function.

  • Adrenergic Agents / metabolism
  • Animals
  • Antigens / immunology
  • Autoimmunity
  • Axotomy
  • CD8-Positive T-Lymphocytes / immunology
  • Denervation
  • Inflammation / pathology
  • Interferon-gamma / metabolism
  • Lymph Nodes / pathology
  • Male
  • Mice, Inbred C57BL
  • Peripheral Nerve Injuries / pathology
  • Sciatic Nerve / immunology
  • Sciatic Nerve / pathology
  • Signal Transduction
  • European Commission - Cell-type specific mechanisms regulating rhythms in leukocyte homing [635872]
Citation (ISO format)
CHEN, Chien-Sin et al. Loss of direct adrenergic innervation after peripheral nerve injury causes lymph node expansion through IFN-γ. In: The journal of experimental medicine, 2021, vol. 218, n° 8, p. e20202377. doi: 10.1084/jem.20202377
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Article (Published version)
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ISSN of the journal0022-1007

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