Influence of circadian clocks on adaptive immunity and vaccination responses

Article Article scientifique Article Influence of circadian clocks on adaptive immunity and vaccination responses eng 2023-01-30 2023-01-30 author Ince Louise 0000-0002-2093-0876 Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Division of Pharmacology & Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX, USA. 899059 author Barnoud Coline 0000-0001-5500-0217 Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 823138 Département de pathologie et immunologie (PATIM) author Lutes Lydia Kay 0000-0001-6133-6294 Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 948114 Département de pathologie et immunologie (PATIM) author Pick Robert 0000-0001-9785-8481 Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 921203 Département de pathologie et immunologie (PATIM) author Wang Chen 0000-0003-2271-5587 Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 894272 Département de pathologie et immunologie (PATIM) author Sinturel Flore 0000-0003-3210-0113 Department of Medicine, Division of Endocrinology, Diabetes, Nutrition and Patient Education, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva, Geneva, Switzerland. 796363 Département de chirurgie (CHIRU) author Chen Chien-Sin Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians-University Munich, BioMedical Centre, Planegg-Martinsried, Germany. author de Juan Alba Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians-University Munich, BioMedical Centre, Planegg-Martinsried, Germany. author Weber Jasmin Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians-University Munich, BioMedical Centre, Planegg-Martinsried, Germany. author Holtkamp Stephan J Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians-University Munich, BioMedical Centre, Planegg-Martinsried, Germany. author Hergenhan Sophia Martina Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians-University Munich, BioMedical Centre, Planegg-Martinsried, Germany. author Geddes-McAlister Jennifer 0000-0002-4257-2096 Experimental Systems Immunology, Max Planck Institute of Biochemistry, Martinsried, Germany.,Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada. author Ebner Stefan Experimental Systems Immunology, Max Planck Institute of Biochemistry, Martinsried, Germany.,Systems Immunology and Proteomics, Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany. author Fontannaz Paola Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,World Health Organization Collaborating Center for Vaccine Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 88291 Département de pathologie et immunologie (PATIM) author Meyer Benjamin 0000-0003-0601-3550 Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,World Health Organization Collaborating Center for Vaccine Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 915879 Département de pathologie et immunologie (PATIM) author Vono Maria Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,World Health Organization Collaborating Center for Vaccine Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 848912 author Jemelin Stéphane Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 116782 Département de pathologie et immunologie (PATIM) author Dibner Charna 0000-0002-4188-803X Department of Medicine, Division of Endocrinology, Diabetes, Nutrition and Patient Education, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva, Geneva, Switzerland. 583541 Département de chirurgie (CHIRU) author Siegrist Claire-Anne 0000-0001-7984-8669 Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.,World Health Organization Collaborating Center for Vaccine Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 26816 Décanat et administration de la faculté de médecine (ADMED) author Meissner Felix 0000-0003-1000-7989 Experimental Systems Immunology, Max Planck Institute of Biochemistry, Martinsried, Germany.,Systems Immunology and Proteomics, Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany. author Graw Frederik 0000-0002-1198-6632 BioQuant - Center for Quantitative Biology, Heidelberg University, Heidelberg, Germany.,Interdisciplinary Center for Scientific Computing, Heidelberg University, Heidelberg, Germany. author Scheiermann Christoph 0000-0002-9212-0995 Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. christoph.scheiermann@unige.ch.,Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva, Geneva, Switzerland. christoph.scheiermann@unige.ch.,Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians-University Munich, BioMedical Centre, Planegg-Martinsried, Germany. christoph.scheiermann@unige.ch.,Geneva Centre for Inflammation Research, Faculty of Medicine, University of Geneva, Geneva, Switzerland. christoph.scheiermann@unige.ch. 891044 Département de pathologie et immunologie (PATIM) 476 10.1038/s41467-023-35979-2 36717561 2041-1723 PMC9885059 https://www.nature.com/articles/s41467-023-35979-2 The adaptive immune response is under circadian control, yet, why adaptive immune reactions continue to exhibit circadian changes over long periods of time is unknown. Using a combination of experimental and mathematical modeling approaches, we show here that dendritic cells migrate from the skin to the draining lymph node in a time-of-day-dependent manner, which provides an enhanced likelihood for functional interactions with T cells. Rhythmic expression of TNF in the draining lymph node enhances BMAL1-controlled ICAM-1 expression in high endothelial venules, resulting in lymphocyte infiltration and lymph node expansion. Lymph node cellularity continues to be different for weeks after the initial time-of-day-dependent challenge, which governs the immune response to vaccinations directed against Hepatitis A virus as well as SARS-CoV-2. In this work, we present a mechanistic understanding of the time-of-day dependent development and maintenance of an adaptive immune response, providing a strategy for using time-of-day to optimize vaccination regimes. Humans Circadian Clocks COVID-19 / prevention & control SARS-CoV-2 Adaptive Immunity Vaccination Lymph Nodes Dewey 616.07 Dewey 616 Dewey 590 European Commission Cell-type specific mechanisms regulating rhythms in leukocyte homing 635872 CIRCODE EU H2020 Swiss National Science Foundation Mechanisms governing rhythmicity in adaptive immune responses 182417 CH Projects German Research Foundation Emmy-Noether grant SCHE 1645/2-1 and SFB914 projects B09 and Z03 Novartis foundation 20A019 Swiss National Science Foundation Roles of the pancreatic islet cell-specific circadian oscillators in metabolic regulation in physiology and type 2 diabetes 184708 CH Projects 137 Département de pathologie et immunologie 21F 56 Département de médecine 221 23 Institut de génétique et de génomique 0DH false 913 Endocrinologie et horloge circadienne 948 1259 L'influence du rôle du cycle circadien sur l'immunité 995 1337 Laboratoire d'immunologie vaccinale humaine 1025 143 Centre de vaccinologie et d'immunologie néonatale 177 https://doi.org/10.26037/yareta:hs6p7nzpkfhrlavgdopkqhafpm https://doi.org/10.26037/yareta:hs6p7nzpkfhrlavgdopkqhafpm https://github.com/GabelHub/ProfileIroning Nature communications 14 1 229e607d-a93b-499d-8c92-2dab5a73e578 Article (Published version) Public Article-scientifique-from-unpaywall.pdf 3294526 application/pdf CC BY-4.0 a6c232b3ee2eb5bd116c74c45c8f1078083efd5b30bb8ad8cbd0e7effecb73a8 5ddb95af-e1fd-465d-a351-6243e6d3240f Appendix Public 41467_2023_35979_MOESM1_ESM.pdf 3005918 application/pdf Figures S1-8, Tables S1-4, Suppl. Note 1 41180823d833fb4fbdef13ba39b1ae8ead78aa11fe27d9ba8364381f02a0bb32 a1f7e76c-9411-4ede-85f9-ce1d071845fc Appendix Public 41467_2023_35979_MOESM2_ESM.pdf 368933 application/pdf Reporting Summary c3188b4fc559cd5bcd5c6fe8247b90aabe4657bbd48175b19f2ba290a1ba9271 26dc0f55-d6ea-4577-bd67-902307d1088b Supplemental data Public 41467_2023_35979_MOESM3_ESM.zip 219607 application/zip 56d75e96b0107933e7055b8f1e4f4569f19c0822989e6e3442832f4700119703 openAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de médecine Centres et instituts / Institut de génétique et de génomique

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