en
Doctoral thesis
English

New multidrug cocktails for treatment-naive and -resistant clear cell renal cell carcinoma

ContributorsRausch, Magdalena
Defense date2021-06-03
Abstract

This thesis presents the research of the development, optimization and in-depth validation of personalizable multidrug combinations to treat clear cell renal cell carcinoma. This was done in ccRCC cells sensitive or resistant to sunitinib – a first-line standard of care, using the in-house developed and validated Therapeutically Guided Multidrug Optimization (TGMO) technology and subsequent pre-clinical in vitro methods to establish optimized multidrug combinations (ODC) to effectively and selectively treat ccRCC. It is anticipated that the information provided in these studies will stimulate future in vivo and potential clinical evaluation of optimized multidrug combinations. The techniques used here should guide personalized drug combinations for cancer treatment in the future.

eng
Keywords
  • Clear cell renal cell carcinoma
  • Drug combinations
  • Drug repurposing
  • Drug resistance
  • Histone deactylase inhibitor
  • Innovative treatment strategy
  • Sunitinib
  • Tumor microenvironment
  • Tyrosine kinase inhibitor
Citation (ISO format)
RAUSCH, Magdalena. New multidrug cocktails for treatment-naive and -resistant clear cell renal cell carcinoma. 2021. doi: 10.13097/archive-ouverte/unige:152941
Main files (1)
Thesis
accessLevelRestricted
Identifiers
303views
29downloads

Technical informations

Creation07/01/2021 2:55:00 PM
First validation07/01/2021 2:55:00 PM
Update time03/19/2024 3:10:04 PM
Status update03/19/2024 3:10:04 PM
Last indexation03/19/2024 3:10:06 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack