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Scientific article
English

Ether lipids, sphingolipids and toxic 1-deoxyceramides as hallmarks for lean and obese type 2 diabetic patients

Published inActa Physiologica, vol. 232, no. 1, e13610
Publication date2021
Abstract

The worldwide increase in obesity and type 2 diabetes (T2D) represents a major health challenge. Chronically altered lipids induced by obesity further promote the development of T2D, and the accumulation of toxic lipid metabolites in serum and peripheral organs may contribute to the diabetic phenotype. To better understand the complex metabolic pattern of lean and obese T2D and non-T2D individuals, we analysed the lipid profile of human serum, skeletal muscle and visceral adipose tissue of two cohorts by systematic mass spectrometry-based lipid analysis.

Keywords
  • 1-deoxyceramide
  • Type 2 diabetes in lean and obese subjects
  • Lipid metabolism
  • Lipidomics
  • Serum
  • Visceral adipose tissue
Funding
Citation (ISO format)
HANNICH, Joerg Thomas et al. Ether lipids, sphingolipids and toxic 1-deoxyceramides as hallmarks for lean and obese type 2 diabetic patients. In: Acta Physiologica, 2021, vol. 232, n° 1, p. e13610. doi: 10.1111/apha.13610
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Identifiers
ISSN of the journal1748-1708
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