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Early experimental COVID-19 therapies: associations with length of hospital stay, mortality and related costs

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Published in Swiss Medical Weekly. 2020, vol. 150, w20446
Abstract Hydroxychloroquine and lopinavir/ritonavir have been used as experimental therapies to treat COVID-19 during the first wave of the pandemic. Randomised controlled trials have recently shown that there are no meaningful benefits of these two therapies in hospitalised patients. Uncertainty remains regarding the potential harmful impact of these therapies as very early treatments and their burden to the health care system. The present study investigated the length of hospital stay (LOS), mortality, and costs of hydroxychloroquine, lopinavir/ritonavir or their combination in comparison with standard of care among patients hospitalised for coronavirus disease 2019 (COVID-19).
Keywords AdolescentAdultAge FactorsAgedAged, 80 and overAntiviral Agents/administration & dosage/adverse effects/therapeutic useCOVID-19/drug therapy/epidemiology/mortalityChildChild, PreschoolComorbidityDrug CombinationsDrug Therapy, CombinationHealth ExpendituresHospital Mortality/trendsHumansHydroxychloroquine/administration & dosage/adverse effects/therapeutic useInfantLength of Stay/statistics & numerical dataLopinavir/administration & dosage/adverse effects/therapeutic useMiddle AgedPandemicsRetrospective StudiesRitonavir/administration & dosage/adverse effects/therapeutic useSARS-CoV-2Severity of Illness IndexSex FactorsSocioeconomic FactorsTherapies, Investigational/methodsYoung Adult
PMID: 33382449
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Research groups Epidémiologie clinique et biostatistique (115)
Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
Pharmaco-omiques et médecine de précision (1003)
VIH/SIDA (930)
Groupe Perrier Arnaud (Médecine interne générale, de réhabilitation et de gériatrie) (585)
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VERNAZ-HEGI, Nathalie et al. Early experimental COVID-19 therapies: associations with length of hospital stay, mortality and related costs. In: Swiss Medical Weekly, 2020, vol. 150, p. w20446. doi: 10.4414/smw.2020.20446 https://archive-ouverte.unige.ch/unige:151585

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Deposited on : 2021-05-11

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