Anticoagulant therapy for acute venous thrombo-embolism in cancer patients: A systematic review and network meta-analysis

Rossel, Anne; Robert-Ebadi, Helia; Combescure, Christophe; Grosgurin, Olivier; Stirnemann, Jérôme; Addeo, Alfredo; Garin, Nicolas; Agoritsas, Thomas; Reny, Jean-Luc; Marti, Christophe

doi:10.1371/journal.pone.0213940

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Title		Anticoagulant therapy for acute venous thrombo-embolism in cancer patients: A systematic review and network meta-analysis
Authors		Rossel, Anne Robert-Ebadi, Helia Combescure, Christophe Grosgurin, Olivier Stirnemann, Jérôme Addeo, Alfredo Garin, Nicolas Agoritsas, Thomas Reny, Jean-Luc Marti, Christophe show all authors [1 - 10]
Published in		PLOS ONE. 2019, vol. 14, no. 3, e0213940
Abstract		Low-molecular-weight heparin (LMWH) is usually recommended for the treatment of cancer-associated thrombosis (CAT) but this treatment requires burdensome daily injections. We did a systematic review to compare the efficacy and safety of direct oral anticoagulants (DOAC), vitamin K antagonists (VKA) and LMWH in patients with CAT.
Keywords		Acute Disease — Administration — Oral — Anticoagulants/administration & dosage/adverse effects/therapeutic use — Factor Xa Inhibitors/administration & dosage/adverse effects/therapeutic use — Female — Hemorrhage/etiology — Heparin — Low-Molecular-Weight/administration & dosage/adverse effects/therapeutic use — Humans — Male — Neoplasms/complications — Network Meta-Analysis — Recurrence — Risk Factors — Safety — Secondary Prevention — Venous Thromboembolism/drug therapy/etiology/prevention & control — Vitamin K/antagonists & inhibitors
Identifiers		DOI: 10.1371/journal.pone.0213940 PMID: 30897142
Full text		Article (Published version) (1.8 MB) - Free access Other version: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428324/
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Centre de recherche clinique
Research groups		Epidémiologie clinique et biostatistique (115) Geneva Platelet Group (13)
Citation (ISO format)		ROSSEL, Anne et al. Anticoagulant therapy for acute venous thrombo-embolism in cancer patients: A systematic review and network meta-analysis. In: PLOS ONE, 2019, vol. 14, n° 3, p. e0213940. doi: 10.1371/journal.pone.0213940 https://archive-ouverte.unige.ch/unige:145169