Accuracy of C-reactive protein, procalcitonin, serum amyloid A and neopterin for low-dose CT-scan confirmed pneumonia in elderly patients: A prospective cohort study

Prendki, Virginie; Malézieux-Picard, Astrid; Azurmendi Gil, Leire; Sanchez, Jean-Charles; Vuilleumier, Nicolas; Carballo, Sebastian; Roux, Xavier; Reny, Jean-Luc; Zekry Berger, Dina Selma; Stirnemann, Jérôme; Garin, Nicolas; PneumOldCT study group

doi:10.1371/journal.pone.0239606

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English

Accuracy of C-reactive protein, procalcitonin, serum amyloid A and neopterin for low-dose CT-scan confirmed pneumonia in elderly patients: A prospective cohort study

ContributorsPrendki, Virginie; Malézieux-Picard, Astrid; Azurmendi Gil, Leire; Sanchez, Jean-Charles

; Vuilleumier, Nicolas; Carballo, Sebastian; Roux, Xavier; Reny, Jean-Luc

; Zekry Berger, Dina Selma; Stirnemann, Jérôme; Garin, Nicolas; PneumOldCT study group

Published inPLOS ONE, vol. 15, no. 9, e0239606

Publication date2020

Abstract

The diagnosis of pneumonia based on semiology and chest X-rays is frequently inaccurate, particularly in elderly patients. Older (C-reactive protein (CRP); procalcitonin (PCT)) or newer (Serum amyloid A (SAA); neopterin (NP)) biomarkers may increase the accuracy of pneumonia diagnosis, but data are scarce and conflicting. We assessed the accuracy of CRP, PCT, SAA, NP and the ratios CRP/NP and SAA/NP in a prospective observational cohort of elderly patients with suspected pneumonia.

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Citation (ISO format)

PRENDKI, Virginie et al. Accuracy of C-reactive protein, procalcitonin, serum amyloid A and neopterin for low-dose CT-scan confirmed pneumonia in elderly patients: A prospective cohort study. In: PLOS ONE, 2020, vol. 15, n° 9, p. e0239606. doi: 10.1371/journal.pone.0239606