en
Scientific article
Open access
English

Human fetal mesoangioblasts reveal tissue-dependent transcriptional signatures

Published inStem Cells Translational Medicine, vol. 9, no. 5, p. 575-589
Publication date2020
Abstract

Mesoangioblasts (MABs) derived from adult skeletal muscles are well-studied adult stem/progenitor cells that already entered clinical trials for muscle regeneration in genetic diseases; however, the transcriptional identity of human fetal MABs (fMABs) remains largely unknown. Herein we analyzed the transcriptome of MABs isolated according to canonical markers from fetal atrium, ventricle, aorta, and skeletal muscles (from 9.5 to 13 weeks of age) to uncover specific gene signatures correlating with their peculiar myogenic differentiation properties inherent to their tissue of origin. RNA-seq analysis revealed for the first time that human MABs from fetal aorta, cardiac (atrial and ventricular), and skeletal muscles display subsets of differentially expressed genes likely representing distinct expression signatures indicative of their original tissue. Identified GO biological processes and KEGG pathways likely account for their distinct differentiation outcomes and provide a set of critical genes possibly predicting future specific differentiation outcomes. This study reveals novel information regarding the potential of human fMABs that may help to improve specific differentiation outcomes relevant for therapeutic muscle regeneration.

Citation (ISO format)
RONZONI, Flavio Lorenzo et al. Human fetal mesoangioblasts reveal tissue-dependent transcriptional signatures. In: Stem Cells Translational Medicine, 2020, vol. 9, n° 5, p. 575–589. doi: 10.1002/sctm.19-0209
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal2157-6564
218views
101downloads

Technical informations

Creation07/10/2020 11:08:00 AM
First validation07/10/2020 11:08:00 AM
Update time03/15/2023 10:23:39 PM
Status update03/15/2023 10:23:38 PM
Last indexation02/12/2024 11:53:53 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack