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High-throughput sequencing for the aetiologic identification of viral encephalitis, meningoencephalitis, and meningitis. A narrative review and clinical appraisal

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Published in Clinical Microbiology and Infection. 2019, vol. 25, no. 4, p. 422-430
Abstract Viral aetiologies are the most common cause of central nervous system (CNS) infections. Approximately one-half of CNS infections remain of undetermined origin. High-throughput sequencing (HTS) brought new perspectives to CNS infection investigations, allowing investigation of viral aetiologies with an unbiased approach. HTS use is still limited to specific clinical situations.
Keywords AdolescentAdultAgedBrain/pathologyChildChildPreschoolEncephalitisViral/diagnosis/virologyFemaleHigh-Throughput Nucleotide SequencingHumansInfantMaleMeningitisViral/diagnosis/virologyMeningoencephalitis/diagnosis/virologyMiddle AgedViruses/classification/genetics/isolation & purificationYoung AdultDiagnosisEncephalitisHigh-throughput sequencingMeningitisMeningoencephalitisVirus
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PMID: 30641229
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Article (Published version) (714 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research groups Analyse génomique et fonctionnelle du staphylocoque doré (604)
Groupe Laurent Kaiser (virologie clinique) (668)
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ZANELLA, Marie-Céline et al. High-throughput sequencing for the aetiologic identification of viral encephalitis, meningoencephalitis, and meningitis. A narrative review and clinical appraisal. In: Clinical Microbiology and Infection, 2019, vol. 25, n° 4, p. 422-430. doi: 10.1016/j.cmi.2018.12.022 https://archive-ouverte.unige.ch/unige:132957

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Deposited on : 2020-03-24

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