High-throughput sequencing for the aetiologic identification of viral encephalitis, meningoencephalitis, and meningitis. A narrative review and clinical appraisal

Zanella, Marie-Céline; Lenggenhager, Lauriane; Schrenzel, Jacques; Cordey, Samuel; Kaiser, Laurent

doi:10.1016/j.cmi.2018.12.022

Scientific article

Review

English

High-throughput sequencing for the aetiologic identification of viral encephalitis, meningoencephalitis, and meningitis. A narrative review and clinical appraisal

ContributorsZanella, Marie-Céline; Lenggenhager, Lauriane; Schrenzel, Jacques; Cordey, Samuel; Kaiser, Laurent

Published inClinical Microbiology and Infection, vol. 25, no. 4, p. 422-430

Publication date2019

Abstract

Viral aetiologies are the most common cause of central nervous system (CNS) infections. Approximately one-half of CNS infections remain of undetermined origin. High-throughput sequencing (HTS) brought new perspectives to CNS infection investigations, allowing investigation of viral aetiologies with an unbiased approach. HTS use is still limited to specific clinical situations.

Keywords

Adolescent
Adult
Aged
Brain/pathology
Child
Child
Preschool
Encephalitis
Viral/diagnosis/virology
Female
High-Throughput Nucleotide Sequencing
Humans
Infant
Male
Meningitis
Viral/diagnosis/virology
Meningoencephalitis/diagnosis/virology
Middle Aged
Viruses/classification/genetics/isolation & purification
Young Adult
Diagnosis
Encephalitis
High-throughput sequencing
Meningitis
Meningoencephalitis
Virus

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Citation (ISO format)

ZANELLA, Marie-Céline et al. High-throughput sequencing for the aetiologic identification of viral encephalitis, meningoencephalitis, and meningitis. A narrative review and clinical appraisal. In: Clinical Microbiology and Infection, 2019, vol. 25, n° 4, p. 422–430. doi: 10.1016/j.cmi.2018.12.022

Article (Published version)

Identifiers

PID : unige:132957
DOI : 10.1016/j.cmi.2018.12.022
PMID : 30641229

Journal ISSN1198-743X

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High-throughput sequencing for the aetiologic identification of viral encephalitis, meningoencephalitis, and meningitis. A narrative review and clinical appraisal

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