No Longitudinal Mitochondrial DNA Sequence Changes in HIV-infected Individuals With and Without Lipoatrophy

Ortiz, M.; Poloni, Estella S.; Furrer, H.; Kovari, H.; Martinez, R.; Arnedo, M.; Elzi, L.; Bernasconi, Enos; Vernazza, P.; Hirschel, Bernard; Cavassini, M.; Ledergerber, B.; Gunthard, H. F.; Telenti, A.; Tarr, P. E.

doi:10.1093/infdis/jiq106

Scientific article

English

No Longitudinal Mitochondrial DNA Sequence Changes in HIV-infected Individuals With and Without Lipoatrophy

Contributors

Ortiz, M.; Poloni, Estella S.

; Furrer, H.; Kovari, H.; Martinez, R.; Arnedo, M.; Elzi, L.; Bernasconi, Enos; Vernazza, P.; Hirschel, Bernard; Cavassini, M.; Ledergerber, B.; Gunthard, H. F.; Telenti, A.; Tarr, P. E.

Published in

Scandinavian journal of infectious diseases, vol. 203, no. 5, p. 620-624

Publication date

2011

Abstract

The potential for mitochondrial (mt) DNA mutation accumulation during antiretroviral therapy (ART), and preferential accumulation in patients with lipoatrophy compared with control participants, remains controversial. We sequenced the entire mitochondrial genome, both before ART and after ART exposure, in 29 human immunodeficiency virus (HIV)–infected Swiss HIV Cohort Study participants initiating a first-line thymidine analogue–containing ART regimen. No accumulation of mtDNA mutations or deletions was detected in 13 participants who developed lipoatrophy or in 16 control participants after significant and comparable ART exposure (median duration, 3.3 and 3.7 years, respectively). In HIV-infected persons, the development of lipoatrophy is unlikely to be associated with accumulation of mtDNA mutations detectable in peripheral blood.

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

ORTIZ, M. et al. No Longitudinal Mitochondrial DNA Sequence Changes in HIV-infected Individuals With and Without Lipoatrophy. In: Scandinavian journal of infectious diseases, 2011, vol. 203, n° 5, p. 620–624. doi: 10.1093/infdis/jiq106

Article (Published version)

Identifiers

PID : unige:13239
DOI : 10.1093/infdis/jiq106
PMID : 21227914

Journal ISSN

0036-5548

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Creation

24/01/2011 10:59:00

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24/01/2011 10:59:00

Update

30/03/2023 10:04:07

Status update

30/03/2023 10:04:06

Last indexation

29/10/2024 17:43:38

No Longitudinal Mitochondrial DNA Sequence Changes in HIV-infected Individuals With and Without Lipoatrophy

Contributors

Published in

Publication date

Abstract

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

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Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation