Human innate lymphoid cells (ILCs): Toward a uniform immune-phenotyping

Trabanelli, Sara; Gomez-Cadena, Alejandra; Salomé, Bérengère; Michaud, Katarzyna; Mavilio, Domenico; Landis, Basile Nicolas; Jandus, Peter; Jandus, Camilla

doi:10.1002/cyto.b.21614

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Title		Human innate lymphoid cells (ILCs): Toward a uniform immune-phenotyping
Authors		Trabanelli, Sara Gomez-Cadena, Alejandra Salomé, Bérengère Michaud, Katarzyna Mavilio, Domenico Landis, Basile Nicolas Jandus, Peter Jandus, Camilla
Published in		Cytometry. Part B, Clinical cytometry. 2018, vol. 94, no. 3, p. 392-399
Abstract		Helper innate lymphoid cells (ILCs), the most recently identified population of the ILC family, play a fundamental role in the restoration of tissue integrity, in the protection against infiltrating pathogens as well as in tumor immune-surveillance. ILCs have been divided into three main subsets, ILC1, ILC2, and ILC3, that can be specifically activated by different signals coming either indirectly from pathogens or from other cell populations, including cancer cells. Following activation, ILCs are in turn able to promptly secrete a wide range of soluble mediators that modulate effector cell functions. The discovery and the study of these immune cells is now offering important opportunities for innovative therapies of allergic airway diseases, inflammatory disorders and might be crucial for the discovery of new targets for the therapy of cancer. It is therefore fundamental that the scientific community establishes harmonized guidelines to obtain a consensus in the identification and phenotypical and functional characterization of ILCs. © 2018 International Clinical Cytometry Society.
Keywords		Animals — Flow Cytometry/methods — Humans — Immunity — Innate/immunology — Immunologic Factors/immunology — Immunophenotyping/methods — Lymphocytes/immunology
Identifiers		DOI: 10.1002/cyto.b.21614 PMID: 29244250
Full text		Article (Published version) (742 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques
Research group		Ciblage des lymphocytes sécrétant des cytokines (1015)
Project		Swiss National Science Foundation: PZOOP3_161459
Citation (ISO format)		TRABANELLI, Sara et al. Human innate lymphoid cells (ILCs): Toward a uniform immune-phenotyping. In: Cytometry. Part B, Clinical cytometry, 2018, vol. 94, n° 3, p. 392-399. doi: 10.1002/cyto.b.21614 https://archive-ouverte.unige.ch/unige:128414