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Human innate lymphoid cells (ILCs): Toward a uniform immune-phenotyping

Trabanelli, Sara
Gomez-Cadena, Alejandra
Salomé, Bérengère
Michaud, Katarzyna
Mavilio, Domenico
Published in Cytometry. Part B, Clinical cytometry. 2018, vol. 94, no. 3, p. 392-399
Abstract Helper innate lymphoid cells (ILCs), the most recently identified population of the ILC family, play a fundamental role in the restoration of tissue integrity, in the protection against infiltrating pathogens as well as in tumor immune-surveillance. ILCs have been divided into three main subsets, ILC1, ILC2, and ILC3, that can be specifically activated by different signals coming either indirectly from pathogens or from other cell populations, including cancer cells. Following activation, ILCs are in turn able to promptly secrete a wide range of soluble mediators that modulate effector cell functions. The discovery and the study of these immune cells is now offering important opportunities for innovative therapies of allergic airway diseases, inflammatory disorders and might be crucial for the discovery of new targets for the therapy of cancer. It is therefore fundamental that the scientific community establishes harmonized guidelines to obtain a consensus in the identification and phenotypical and functional characterization of ILCs. © 2018 International Clinical Cytometry Society.
Keywords AnimalsFlow Cytometry/methodsHumansImmunityInnate/immunologyImmunologic Factors/immunologyImmunophenotyping/methodsLymphocytes/immunology
PMID: 29244250
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Article (Published version) (742 Kb) - public document Free access
Research group Ciblage des lymphocytes sécrétant des cytokines (1015)
Swiss National Science Foundation: PZOOP3_161459
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TRABANELLI, Sara et al. Human innate lymphoid cells (ILCs): Toward a uniform immune-phenotyping. In: Cytometry. Part B, Clinical cytometry, 2018, vol. 94, n° 3, p. 392-399. doi: 10.1002/cyto.b.21614 https://archive-ouverte.unige.ch/unige:128414

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Deposited on : 2020-01-08

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