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Scientific article
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English

Anti-angiogenic effects of crenolanib are mediated by mitotic modulation independently of PDGFR expression

Published inBritish Journal of Cancer, vol. 121, no. 2, p. 139-149
Publication date2019
Abstract

Crenolanib is a tyrosine kinase inhibitor targeting PDGFR-α, PDGFR-β and Fms related tyrosine kinase-3 (FLT3) that is currently evaluated in several clinical trials. Although platelet-derived growth factor receptor (PDGFR) signalling pathway is believed to play an important role in angiogenesis and maintenance of functional vasculature, we here demonstrate a direct angiostatic activity of crenolanib independently of PDGFR signalling.

Citation (ISO format)
BERNDSEN, Robert H et al. Anti-angiogenic effects of crenolanib are mediated by mitotic modulation independently of PDGFR expression. In: British Journal of Cancer, 2019, vol. 121, n° 2, p. 139–149. doi: 10.1038/s41416-019-0498-2
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ISSN of the journal0007-0920
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Creation2019/08/08 13:03:00
First validation2019/08/08 13:03:00
Update time2023/03/15 17:50:35
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