Anti-angiogenic effects of crenolanib are mediated by mitotic modulation independently of PDGFR expression

Article Article scientifique Article Anti-angiogenic effects of crenolanib are mediated by mitotic modulation independently of PDGFR expression eng 2019 author Berndsen Robert H author Castrogiovanni Cédric 913443 author Weiss Andrea author Rausch Magdalena 897516 author Dallinga Marchien G author Miljkovic Marajana 589774 author Klaassen Ingeborg author Meraldi Patrick 0000-0001-9742-8756 108140 author van Beijnum Judy R author Nowak-Sliwinska Patrycja 848409 139-149 10.1038/s41416-019-0498-2 31235865 0007-0920 Crenolanib is a tyrosine kinase inhibitor targeting PDGFR-α, PDGFR-β and Fms related tyrosine kinase-3 (FLT3) that is currently evaluated in several clinical trials. Although platelet-derived growth factor receptor (PDGFR) signalling pathway is believed to play an important role in angiogenesis and maintenance of functional vasculature, we here demonstrate a direct angiostatic activity of crenolanib independently of PDGFR signalling. Dewey 612 Dewey 615 Dewey 616.07 Swiss National Science Foundation Investigating the role of the centrosome in the mitotic spindle 179413 CH Project funding Autre ERC-StG-2015–680209 31 Section des sciences pharmaceutiques 17 134 Département de physiologie cellulaire et métabolisme 21C 137 Département de pathologie et immunologie 21F false 579 Groupe Meraldi Patrick (physiologie cellulaire et métabolisme) 922 1325 Pharmacologie moléculaire British Journal of Cancer 121 2 6059d653-d234-451f-ba3f-8151f8275639 Article (Published version) Public s41416-019-0498-2.pdf 4184269 application/pdf CC BY openAccess Faculté des sciences / Section des sciences pharmaceutiques Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

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Anti-angiogenic effects of crenolanib are mediated by mitotic modulation independently of PDGFR expression	British Journal of Cancer			2019	461	235

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Miljkovic, Marajana