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Title

Macrophage migration inhibitory factor regulates TLR4 expression and modulates TCR/CD3-mediated activation in CD4+ T lymphocytes

Authors
Roger, Thierry
Published in Scientific Reports. 2019, vol. 9, no. 1, p. 9380
Abstract Toll-like receptor 4 (TLR4) is involved in CD4+ T lymphocyte-mediated pathologies. Here, we demonstrate that CD4+ T lymphocytes express functional TLR4 that contributes to their activation, proliferation and cytokine secretion. In addition, we demonstrate that TLR4-induced responses are mediated by macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine. We also demonstrate that MIF regulates suboptimal TCR/CD3-mediated activation of T lymphocytes. On one hand, MIF prevents excessive TCR/CD3-mediated activation of CD4+ T lymphocytes under suboptimal stimulation conditions and, on the other hand, MIF enables activated CD4+ T lymphocytes to sense their microenvironment and adapt their effector response through TLR4. Therefore, MIF appears to be a major regulator of the activation of CD4+ T lymphocytes and the intensity of their effector response. TLR4-mediated activation is thus an important process for T cell-mediated immunity.
Identifiers
PMID: 31253838
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Structures
Research group La transplantation d'îlots de Langerhans (623)
Projects FNS: grant number 310030-149798
FNS: grant number 173123
Citation
(ISO format)
ALIBASHE AHMED, Mohamed et al. Macrophage migration inhibitory factor regulates TLR4 expression and modulates TCR/CD3-mediated activation in CD4+ T lymphocytes. In: Scientific Reports, 2019, vol. 9, n° 1, p. 9380. https://archive-ouverte.unige.ch/unige:121103

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Deposited on : 2019-07-23

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