UNIGE document Scientific Article
previous document  unige:116904  next document
add to browser collection

A switch between topological domains underlies HoxD genes collinearity in mouse limbs

Noordermeer, Daan
Leleu, Marion
show hidden authors show all authors [1 - 9]
Published in Science. 2013, vol. 340, no. 6137, 1234167
Abstract Hox genes are major determinants of the animal body plan, where they organize structures along both the trunk and appendicular axes. During mouse limb development, Hoxd genes are transcribed in two waves: early on, when the arm and forearm are specified, and later, when digits form. The transition between early and late regulations involves a functional switch between two opposite topological domains. This switch is reflected by a subset of Hoxd genes mapping centrally into the cluster, which initially interact with the telomeric domain and subsequently swing toward the centromeric domain, where they establish new contacts. This transition between independent regulatory landscapes illustrates both the modularity of the limbs and the distinct evolutionary histories of its various pieces. It also allows the formation of an intermediate area of low HOX proteins content, which develops into the wrist, the transition between our arms and our hands. This regulatory strategy accounts for collinear Hox gene regulation in land vertebrate appendages.
Keywords AnimalsForelimb/embryologyGene Expression RegulationDevelopmentalGene OrderGenesHomeoboxGenesSwitchMiceMiceInbred C57BLMiceTransgenicMultigene FamilyTelomere/geneticsTranscriptionGenetic
PMID: 23744951
Full text
Article (Published version) (1.4 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research groups Contrôle épigénétique du développement embryonnaire (999)
Groupe Duboule
Swiss National Science Foundation: NCCR “Frontiers in Genetics – Genes, Chromosomes and Development”
(ISO format)
ANDREY, Guillaume et al. A switch between topological domains underlies HoxD genes collinearity in mouse limbs. In: Science, 2013, vol. 340, n° 6137, p. 1234167. doi: 10.1126/science.1234167 https://archive-ouverte.unige.ch/unige:116904

271 hits

1 download


Deposited on : 2019-05-03

Export document
Format :
Citation style :