Scientific article

A switch between topological domains underlies HoxD genes collinearity in mouse limbs

Published inScience, vol. 340, no. 6137, 1234167
Publication date2013

Hox genes are major determinants of the animal body plan, where they organize structures along both the trunk and appendicular axes. During mouse limb development, Hoxd genes are transcribed in two waves: early on, when the arm and forearm are specified, and later, when digits form. The transition between early and late regulations involves a functional switch between two opposite topological domains. This switch is reflected by a subset of Hoxd genes mapping centrally into the cluster, which initially interact with the telomeric domain and subsequently swing toward the centromeric domain, where they establish new contacts. This transition between independent regulatory landscapes illustrates both the modularity of the limbs and the distinct evolutionary histories of its various pieces. It also allows the formation of an intermediate area of low HOX proteins content, which develops into the wrist, the transition between our arms and our hands. This regulatory strategy accounts for collinear Hox gene regulation in land vertebrate appendages.

  • Animals
  • Forelimb/embryology
  • Gene Expression Regulation
  • Developmental
  • Gene Order
  • Genes
  • Homeobox
  • Genes
  • Switch
  • Mice
  • Mice
  • Inbred C57BL
  • Mice
  • Transgenic
  • Multigene Family
  • Telomere/genetics
  • Transcription
  • Genetic
  • Swiss National Science Foundation - NCCR “Frontiers in Genetics – Genes, Chromosomes and Development”
Citation (ISO format)
ANDREY, Guillaume et al. A switch between topological domains underlies <i>HoxD</i> genes collinearity in mouse limbs. In: Science, 2013, vol. 340, n° 6137, p. 1234167. doi: 10.1126/science.1234167
Main files (1)
Article (Published version)
ISSN of the journal0036-8075

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