Welfare regimes in Europe modify individuals' socioeconomic trajectories over their life-course, and, ultimately, the link between socioeconomic circumstances (SECs) and health. This paper aimed to assess whether the associations between life-course SECs (earlylife, young adult-life, middle age and old age) and risk of poor self-rated health (SRH) trajectories in old age are modified by welfare regime (Scandinavian [SC], Bismarckian [BM], Southern European [SE], Eastern European [EE]).