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Scientific article
English

Xeno-free derivation and culture of human embryonic stem cells: current status, problems and challenges

Published inCell Research, vol. 17, no. 8, p. 682-688
Publication date2007
Abstract

Human embryonic stem cells (hESC) not only hold great promise for the treatment of degenerative diseases but also provide a valuable tool for developmental studies. However, the clinical applications of hESC are at present limited by xeno-contamination during the in vitro derivation and propagation of these cells. In this review, we summarize the current methodologies for the derivation and the propagation of hESC in conditions that will eventually enable the generation of clinical-grade cells for future therapeutic applications.

Keywords
  • Cell Culture Techniques/methods/trends
  • Cell Proliferation
  • Culture Media/chemistry/pharmacology
  • Embryonic Stem Cells/ cytology/drug effects
  • Humans
  • Models, Biological
Citation (ISO format)
LEI, Ting et al. Xeno-free derivation and culture of human embryonic stem cells: current status, problems and challenges. In: Cell Research, 2007, vol. 17, n° 8, p. 682–688. doi: 10.1038/cr.2007.61
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ISSN of the journal1001-0602
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