UNIGE document Doctoral Thesis
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Development of new chemical and physical strategies to enhance topical drug delivery

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Defense Thèse de doctorat : Univ. Genève, 2018 - Sc. 5214 - 2018/04/27
Abstract This project investigated the non-invasive iontophoretic delivery of novel triamcinolone acetonide amino acid prodrugs (TA-AA) synthesized in-house, to the eye and skin. Chapter 1 contains an exhaustive literature research on ocular iontophoresis. Chapter 2 describes the intracorneal iontophoresis of two TA-AA prodrugs, focusing on the quantitative (UHPLC-MS/MS) and qualitative (visualization by full field optical coherence tomography) evaluation of TA biodistribution. Chapter 3 presents the intracorneal distribution of 10 TA-AA prodrugs with analysis of the delivery of each individual prodrug in terms of its physicochemical properties. Chapter 4 describes the transscleral iontophoresis, using the entire eye globe, of selected TA-AA prodrugs and the quantification of TA in the different ocular compartments as a non-invasive alternative to ocular corticosteroid injections. Chapter 5 contains a detailed analysis of TA-AA prodrugs iontophoretic delivery into the skin as well as the co-iontophoretic delivery of TA-Arg (arginine) with the calcium channel blocker verapamil.
Keywords Triamcinolone acetonideVerapamilAmino acidProdrugIontophoresisAnalysisBiodistributionEyeTransscleralTranscornealSkinTopical delivery
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URN: urn:nbn:ch:unige-1052662
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Thesis (5.3 MB) - document accessible for UNIGE members only Limited access to UNIGE (until 2019-03-06)
Other version: https://nbn-resolving.org/urn:nbn:ch:unige-1052662
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SANTER, Verena. Development of new chemical and physical strategies to enhance topical drug delivery. Université de Genève. Thèse, 2018. https://archive-ouverte.unige.ch/unige:105266

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Deposited on : 2018-06-08

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