en
Doctoral thesis
Open access
English

Development of new chemical and physical strategies to enhance topical drug delivery

ContributorsSanter, Verena
Defense date2018-04-27
Abstract

This project investigated the non-invasive iontophoretic delivery of novel triamcinolone acetonide amino acid prodrugs (TA-AA) synthesized in-house, to the eye and skin. Chapter 1 contains an exhaustive literature research on ocular iontophoresis. Chapter 2 describes the intracorneal iontophoresis of two TA-AA prodrugs, focusing on the quantitative (UHPLC-MS/MS) and qualitative (visualization by full field optical coherence tomography) evaluation of TA biodistribution. Chapter 3 presents the intracorneal distribution of 10 TA-AA prodrugs with analysis of the delivery of each individual prodrug in terms of its physicochemical properties. Chapter 4 describes the transscleral iontophoresis, using the entire eye globe, of selected TA-AA prodrugs and the quantification of TA in the different ocular compartments as a non-invasive alternative to ocular corticosteroid injections. Chapter 5 contains a detailed analysis of TA-AA prodrugs iontophoretic delivery into the skin as well as the co-iontophoretic delivery of TA-Arg (arginine) with the calcium channel blocker verapamil.

eng
Keywords
  • Triamcinolone acetonide
  • Verapamil
  • Amino acid
  • Prodrug
  • Iontophoresis
  • Analysis
  • Biodistribution
  • Eye
  • Transscleral
  • Transcorneal
  • Skin
  • Topical delivery
Citation (ISO format)
SANTER, Verena. Development of new chemical and physical strategies to enhance topical drug delivery. 2018. doi: 10.13097/archive-ouverte/unige:105266
Main files (1)
Thesis
accessLevelPublic
Identifiers
534views
332downloads

Technical informations

Creation06/06/2018 7:50:00 PM
First validation06/06/2018 7:50:00 PM
Update time03/15/2023 8:19:13 AM
Status update03/15/2023 8:19:12 AM
Last indexation01/29/2024 9:29:42 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack