Development of new chemical and physical strategies to enhance topical drug delivery

Diplôme Thèse Development of new chemical and physical strategies to enhance topical drug delivery eng 2018-04-27 author Santer Verena 785730 director Kalia Yogeshvar 0000-0001-9049-5489 503798 director Scapozza Leonardo 600318 10.13097/archive-ouverte/unige:105266 urn:nbn:ch:unige-1052662 Sc. 5214 This project investigated the non-invasive iontophoretic delivery of novel triamcinolone acetonide amino acid prodrugs (TA-AA) synthesized in-house, to the eye and skin. Chapter 1 contains an exhaustive literature research on ocular iontophoresis. Chapter 2 describes the intracorneal iontophoresis of two TA-AA prodrugs, focusing on the quantitative (UHPLC-MS/MS) and qualitative (visualization by full field optical coherence tomography) evaluation of TA biodistribution. Chapter 3 presents the intracorneal distribution of 10 TA-AA prodrugs with analysis of the delivery of each individual prodrug in terms of its physicochemical properties. Chapter 4 describes the transscleral iontophoresis, using the entire eye globe, of selected TA-AA prodrugs and the quantification of TA in the different ocular compartments as a non-invasive alternative to ocular corticosteroid injections. Chapter 5 contains a detailed analysis of TA-AA prodrugs iontophoretic delivery into the skin as well as the co-iontophoretic delivery of TA-Arg (arginine) with the calcium channel blocker verapamil. Triamcinolone acetonide Verapamil Amino acid Prodrug Iontophoresis Analysis Biodistribution Eye Transscleral Transcorneal Skin Topical delivery Dewey 615 31 Section des sciences pharmaceutiques 17 false ad42c554-e995-4d4f-854d-d13d01c11381 Thesis Public ThesisSANTER.pdf 5518275 application/pdf Restricted 2019-03-06 5e2a6b08a7cbb58c52f4c8dad7449deeb80a3221c2ff1a0dd373391b3f53d122 openAccess Faculté des sciences / Section des sciences pharmaceutiques

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Development of new chemical and physical strategies to enhance topical drug delivery				2018	810	635

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Santer, Verena