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Scientific article
English

The role of neural cell adhesion molecules in plasticity and repair

Published inCurrent opinion in neurobiology, vol. 36, no. 2-3, p. 175-184
Publication date2001
Abstract

Repair and functional recovery after brain injury critically depends on structural and functional plasticity of preserved neuronal networks. A striking feature of brain structures where tissue reorganization and plasticity occur is a strong expression of the polysialylated neural cell adhesion molecule (PSA-NCAM). An important role of this molecule in various aspects of neuronal and synaptic plasticity has been revealed by many studies. Recently, a new mechanism has been elucidated whereby PSA-NCAM may contribute to signalling mediated by the neurotrophic factor BDNF, thereby sensitizing neurons to this growth factor. This mechanism was shown to be important for activity-induced synaptic plasticity and for the survival and differentiation of cortical neurons. A cross-talk between these molecules may, thus, reveal a key factor for properties of structural plasticity and in particular could mediate the activity-dependent aspects of synaptic network remodeling. Animal models have been developed to assess the role of these molecules in functional recovery after lesions.

Keywords
  • Animals
  • Brain Injuries/ metabolism/physiopathology
  • Cell Communication/physiology
  • Humans
  • Nerve Net/growth & development/ injuries/metabolism
  • Neural Cell Adhesion Molecules/ metabolism
  • Neuronal Plasticity/ physiology
  • Recovery of Function/ physiology
  • Signal Transduction/physiology
  • Synapses/metabolism
Citation (ISO format)
KISS, Jozsef Zoltan et al. The role of neural cell adhesion molecules in plasticity and repair. In: Current opinion in neurobiology, 2001, vol. 36, n° 2-3, p. 175–184. doi: 10.1016/S0165-0173(01)00093-5
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ISSN of the journal0959-4388
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