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Scientific article
English

Effects of ketamine on the developing central nervous system

Contributors

Vutskits, Laszlo; Gascon, Eduardo; Kiss, Jozsef Zoltan

Published in

Ideggyógyászati szemle, vol. 60, no. 3-4, p. 109-112

Publication date

2007

Abstract

Ketamine is a widely used drug in pediatric anesthesia practice, acting primarily through the blockade of the N-methyl-D-aspartate (NMDA) type of glutamate receptors. A growing body of laboratory evidence, accumulated during the past few years, suggests that this drug could have potential adverse effects on the developing central nervous system. The goal of this short review is to give a brief synopsis of experimental work indicating ketamine-induced developmental neurotoxicity as well as to discuss potential limitations concerning extrapolation of these studies to clinical practice.

Keywords

  • Anesthetics, Dissociative/ adverse effects
  • Animals
  • Brain/ drug effects/growth & development
  • Central Nervous System/ drug effects
  • Humans
  • Ketamine/ adverse effects
  • Neurotoxicity Syndromes/ etiology
  • Receptors, N-Methyl-D-Aspartate/ antagonists & inhibitors/metabolism

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

VUTSKITS, Laszlo, GASCON, Eduardo, KISS, Jozsef Zoltan. Effects of ketamine on the developing central nervous system. In: Ideggyógyászati szemle, 2007, vol. 60, n° 3-4, p. 109–112.

Identifiers

Journal ISSN

0019-1442
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Technical informations

Creation

06/08/2010 10:47:28

First validation

06/08/2010 10:47:28

Update

14/10/2025 05:55:22

Status update

14/03/2023 15:57:39

Last indexation

20/04/2026 16:18:52
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