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Effects of ketamine on the developing central nervous system

Published in Ideggyogyaszati Szemle. 2007, vol. 60, no. 3-4, p. 109-112
Abstract Ketamine is a widely used drug in pediatric anesthesia practice, acting primarily through the blockade of the N-methyl-D-aspartate (NMDA) type of glutamate receptors. A growing body of laboratory evidence, accumulated during the past few years, suggests that this drug could have potential adverse effects on the developing central nervous system. The goal of this short review is to give a brief synopsis of experimental work indicating ketamine-induced developmental neurotoxicity as well as to discuss potential limitations concerning extrapolation of these studies to clinical practice.
Keywords Anesthetics, Dissociative/ adverse effectsAnimalsBrain/ drug effects/growth & developmentCentral Nervous System/ drug effectsHumansKetamine/ adverse effectsNeurotoxicity Syndromes/ etiologyReceptors, N-Methyl-D-Aspartate/ antagonists & inhibitors/metabolism
Stable URL http://archive-ouverte.unige.ch/unige:10146
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PMID: 17451049
Research group Progéniteurs neuronaux

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Deposited on : 2010-08-06

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