Scientific article
Open access

Influence of circadian clocks on adaptive immunity and vaccination responses

Published inNature communications, vol. 14, no. 1, 476
Publication date2023-01-30
First online date2023-01-30

The adaptive immune response is under circadian control, yet, why adaptive immune reactions continue to exhibit circadian changes over long periods of time is unknown. Using a combination of experimental and mathematical modeling approaches, we show here that dendritic cells migrate from the skin to the draining lymph node in a time-of-day-dependent manner, which provides an enhanced likelihood for functional interactions with T cells. Rhythmic expression of TNF in the draining lymph node enhances BMAL1-controlled ICAM-1 expression in high endothelial venules, resulting in lymphocyte infiltration and lymph node expansion. Lymph node cellularity continues to be different for weeks after the initial time-of-day-dependent challenge, which governs the immune response to vaccinations directed against Hepatitis A virus as well as SARS-CoV-2. In this work, we present a mechanistic understanding of the time-of-day dependent development and maintenance of an adaptive immune response, providing a strategy for using time-of-day to optimize vaccination regimes.

  • Humans
  • Circadian Clocks
  • COVID-19 / prevention & control
  • SARS-CoV-2
  • Adaptive Immunity
  • Vaccination
  • Lymph Nodes
Citation (ISO format)
INCE, Louise et al. Influence of circadian clocks on adaptive immunity and vaccination responses. In: Nature communications, 2023, vol. 14, n° 1, p. 476. doi: 10.1038/s41467-023-35979-2
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Article (Published version)
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ISSN of the journal2041-1723

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