Optimization of the kinetics of cooling of kidneys: a pig model

Article Article scientifique Article Optimization of the kinetics of cooling of kidneys: a pig model eng 1999 author Savioz Daniel 33023 author Jeanjacquot A author Savioz Mélanie 825675 author Ludwig Corinna 37291 author Chilcott Michael John 36065 author Bolle Jean François 97722 author Graf Jean-Daniel 526519 author Nastasi A author Morel Philippe 22337 3-8 10.1159/000008615 10072605 0014-312X We determined the kinetics of cooling in multiple organ procurement for the kidney in a pig model. A biometric analysis by regression enables us to define the factors which influence the rate of temperature decrease: weight of the donor, average rate of perfusion and difference of temperature between the rectal temperature and the temperature of the perfusion solution at initiation of cooling. The description of the temperature as a function of time follows an exponential model of the type T(t) = T0. e(dt) where d is the rate of decrease. The rate of decrease varies according to the above factors. The cellular viability ratio (CVR), was correlated to the rate of cooling. The mean CVR was 91% (SD 4.95) when the rate of cooling was more than 1 degrees C/min. This was compared to 75% (SD 11.17) when the rate was less than 1 degrees C/min (p = 0.023). Our experience leads us to believe that the average cooling rate is frequently too low (<1 degrees C/min). This model can be used to predict and control the kinetics of cooling and may help to define the best way of cooling for future xenotransplantation. Animals Cell Survival Cold Temperature Kidney/cytology/physiology Kidney Transplantation Kinetics Models, Biological Organ Preservation/methods Swine Transplantation, Heterologous Dewey 617 57 Département de chirurgie 222 false 79 Chirurgie viscérale 104 1329 Chirurgie viscérale (HUG) European surgical research 31 1 2cd125bb-6727-4208-8b40-8577adf09a09 Article (Published version) Restricted 8615.pdf 311265 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de chirurgie

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