Early signal from the hippocampus for memory encoding

Article Article scientifique Article Early signal from the hippocampus for memory encoding eng 2020 author Raynal Elsa Jeanne Nicole 804889 author Schnider Armin 124141 author Manuel Aurélie 562491 114-120 10.1002/hipo.23137 31298449 1050-9631 The mediotemporal lobe (MTL), including the hippocampus, is involved in all stages of episodic memory including memory encoding, consolidation, and retrieval. However, the exact timing of the hippocampus' involvement immediately after stimulus encounter remains unclear. In this study, we used high-density 156-channel electroencephalography to study the processing of entirely new stimuli, which had to be encoded, in comparison to highly overlearned stimuli. Sixteen healthy subjects performed a continuous recognition task with meaningful pictures repeated up to four consecutive times. Waveform and topographic cluster analyses of event-related potentials revealed that new items, in comparison to repetitions, were processed significantly differently at 220-300 ms. Source estimation localized activation for processing new stimuli in the right MTL. Our study demonstrates the occurrence of a transient signal from the MTL in response to new information already at 200-300 ms poststimulus onset, which presumably reflects encoding as an initial step toward memory consolidation. EEG Encoding Event-related potentials Hippocampus Mediotemporal lobe Novelty detection Dewey 616.8 Swiss National Science Foundation Orbitofrontal Reality Filtering: Diagnosis and Mechanisms 175472 CH Project funding 61 Département des neurosciences cliniques 226 false 227 Amnésie 289 Hippocampus 30 2 b3fd4948-6765-4236-92e4-098bd0e1d643 Article (Published version) Restricted hipo.23137.pdf 1270214 application/pdf fa21fe9d-9963-4968-9759-909e7c4ce5d5 Article (Accepted version) Public _system_appendPDF_proof_hi.pdf 720809 application/pdf Restricted 2020-07-29 openAccess Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

Title	Published in	Year	Views	Downloads

Early signal from the hippocampus for memory encoding	Hippocampus	2020	363	613
Early medial temporal lobe signature of encoding		2017	107	16

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Raynal, Elsa Jeanne Nicole