Antiestrogen therapy for breast cancer modifies the risk of subsequent cutaneous melanoma

Article Article scientifique Article Antiestrogen therapy for breast cancer modifies the risk of subsequent cutaneous melanoma eng 2012 author Huber Caroline 525986 author Bouchardy Magnin Christine 27853 author Schaffar Robin 673899 author Neyroud Isabelle 23009 author Vlastos Georges 34925 author Le Gal Frédérique-Anne 134548 author Rapiti Aylward Elisabetta 134294 author Benhamou Simone 689191 82-88 10.1158/1940-6207.CAPR-11-0332 21933913 1940-6215 Increased risk of secondary melanoma after breast cancer has been reported. Several lines of evidence suggest that elevated estrogen levels may be implicated in melanoma etiology. Accordingly, use of antiestrogens should be associated with decreased risk of melanoma. We compared melanoma incidence among a cohort of breast cancer patients with and without antiestrogen therapy, with data from the Geneva Cancer Registry. The cohort consisted of 7,360 women diagnosed with breast cancer between 1980 and 2005. About 54% of these patients received antiestrogens. All women were followed until December 2008. We compared cutaneous melanoma incidence rates among patients with and without antiestrogens with those expected in the general population by age and period standardized incidence ratios (SIR). A total of 34 women developed a melanoma during the follow-up period. Compared with the general population, the risk of melanoma was higher for patients who did not receive antiestrogens (SIR: 1.60, 95% CI: 1.08-2.12, P = 0.02). On the contrary, the risk was close to 1 (SIR: 0.98, 95% CI: 0.40-1.56, P = 0.57) for patients who received antiestrogen therapy. This study suggests that antiestrogen therapy modifies the risk of melanoma after breast cancer. Although our results are in agreement with the hypothesis that estrogens could play a role in melanoma occurrence, they need to be replicated in a larger study with data on potential confounders. . Adult Aged Breast Neoplasms/complications/drug therapy Cohort Studies Estrogen Antagonists/therapeutic use Estrogens/metabolism Female Humans Melanoma/etiology/secondary Middle Aged Neoplasms, Second Primary/etiology Registries Risk Skin Neoplasms/etiology/secondary Treatment Outcome Dewey 613 Dewey 616 Dewey 618 56 Département de médecine 221 58 Département de pédiatrie, gynécologie et obstétrique 223 215 Registre genevois des tumeurs 22A12 false 1311 Epidémiologie des tumeurs 1017 277 Groupe Bouchardy Magnin Christine (Registre genevois des tumeurs) 532 590 Prévention du cancer du col utérin 933 Cancer prevention research 5 1 f53d03a5-3dba-4b6e-a034-ad1d0782d11b Article (Published version) Restricted Huber-2012-Antiestrogen therapy.pdf 244916 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires / Institut de santé globale / Registre genevois des tumeurs

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Huber, Caroline