UNIGE document Scientific Article
previous document  unige:31796  next document
add to browser collection
Title

Antiestrogen therapy for breast cancer modifies the risk of subsequent cutaneous melanoma

Authors
Published in Cancer Prevention Research. 2012, vol. 5, no. 1, p. 82-8
Abstract Increased risk of secondary melanoma after breast cancer has been reported. Several lines of evidence suggest that elevated estrogen levels may be implicated in melanoma etiology. Accordingly, use of antiestrogens should be associated with decreased risk of melanoma. We compared melanoma incidence among a cohort of breast cancer patients with and without antiestrogen therapy, with data from the Geneva Cancer Registry. The cohort consisted of 7,360 women diagnosed with breast cancer between 1980 and 2005. About 54% of these patients received antiestrogens. All women were followed until December 2008. We compared cutaneous melanoma incidence rates among patients with and without antiestrogens with those expected in the general population by age and period standardized incidence ratios (SIR). A total of 34 women developed a melanoma during the follow-up period. Compared with the general population, the risk of melanoma was higher for patients who did not receive antiestrogens (SIR: 1.60, 95% CI: 1.08-2.12, P = 0.02). On the contrary, the risk was close to 1 (SIR: 0.98, 95% CI: 0.40-1.56, P = 0.57) for patients who received antiestrogen therapy. This study suggests that antiestrogen therapy modifies the risk of melanoma after breast cancer. Although our results are in agreement with the hypothesis that estrogens could play a role in melanoma occurrence, they need to be replicated in a larger study with data on potential confounders. .
Keywords AdultAgedBreast Neoplasms/complications/drug therapyCohort StudiesEstrogen Antagonists/therapeutic useEstrogens/metabolismFemaleHumansMelanoma/etiology/secondaryMiddle AgedNeoplasms, Second Primary/etiologyRegistriesRiskSkin Neoplasms/etiology/secondaryTreatment Outcome
Identifiers
PMID: 21933913
Full text
Article (Published version) (239 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Groupe Petignat Patrick (933)
Groupe Bouchardy Magnin Christine (Registre genevois des tumeurs) (532)
Citation
(ISO format)
HUBER, Caroline et al. Antiestrogen therapy for breast cancer modifies the risk of subsequent cutaneous melanoma. In: Cancer Prevention Research, 2012, vol. 5, n° 1, p. 82-8. https://archive-ouverte.unige.ch/unige:31796

180 hits

0 download

Update

Deposited on : 2013-12-05

Export document
Format :
Citation style :