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Measurement of Partition-Coefficient Using Centrifugal Partition Chromatography - Method Development and Application to the Determination of Solute Properties

Authors
Tsai, Ruey-Shiuan
Testa, Bernard
Published in Abstracts of Papers - American Chemical Society, National Meeting. 1995, vol. 593, p. 143-154
Abstract Measurement of partition coefficients in various solvent systems has been developed using flow-through centrifugal partition chromatography (CPC). The present paper details the experimental design, and shows that this method is able to measure compounds in a log P range of ca. -3.2 to 3.2 in a precise, accurate and rapid way. The usefulness of some lipophilicity-derived parameters such as Delta log P-oct-alk (log P-octanol minus log P-alkane, reflecting mainly the hydrogen bond donor acidity of solutes) was thus reinforced due to the timely development of this method. We also demonstrated the application of the Delta log P parameter both in characterizing the structural properties of drugs and in uncovering their pharmacological implications
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TSAI, Ruey-Shiuan, CARRUPT, Pierre-Alain, TESTA, Bernard. Measurement of Partition-Coefficient Using Centrifugal Partition Chromatography - Method Development and Application to the Determination of Solute Properties. In: Abstracts of Papers - American Chemical Society, National Meeting, 1995, vol. 593, p. 143-154. https://archive-ouverte.unige.ch/unige:9996

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Deposited on : 2010-08-06

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