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Measurement of Partition-Coefficient Using Centrifugal Partition Chromatography - Method Development and Application to the Determination of Solute Properties

Published inAbstracts of papers - American Chemical Society, vol. 593, p. 143-154
Publication date1995
Abstract

Measurement of partition coefficients in various solvent systems has been developed using flow-through centrifugal partition chromatography (CPC). The present paper details the experimental design, and shows that this method is able to measure compounds in a log P range of ca. -3.2 to 3.2 in a precise, accurate and rapid way. The usefulness of some lipophilicity-derived parameters such as Delta log P-oct-alk (log P-octanol minus log P-alkane, reflecting mainly the hydrogen bond donor acidity of solutes) was thus reinforced due to the timely development of this method. We also demonstrated the application of the Delta log P parameter both in characterizing the structural properties of drugs and in uncovering their pharmacological implications

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Citation (ISO format)
TSAI, Ruey-Shiuan, CARRUPT, Pierre-Alain, TESTA, Bernard. Measurement of Partition-Coefficient Using Centrifugal Partition Chromatography - Method Development and Application to the Determination of Solute Properties. In: Abstracts of papers - American Chemical Society, 1995, vol. 593, p. 143–154. doi: 10.1021/bk-1995-0593.ch013
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ISSN of the journal0065-7727
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