Clinical Course and Management of Iatrogenic Cushing’s Syndrome after Co-Administration of Injected-Triamcinolone and Ritonavir: a Systematic Review

John, Gregor Raphaël; Ollo, Diana; Meyer, Patrick; Herold, Markus; Samer, Caroline Flora; Calmy, Alexandra

doi:10.4172/jaa.1000086

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Title		Clinical Course and Management of Iatrogenic Cushing’s Syndrome after Co-Administration of Injected-Triamcinolone and Ritonavir: a Systematic Review
Authors		John, Gregor Raphaël Ollo, Diana Meyer, Patrick Herold, Markus Samer, Caroline Flora Calmy, Alexandra
Published in		Journal of Antivirals and Antiretrovirals. 2013, vol. 05, no. 07
Abstract		Iatrogenic Cushing Syndrome (ICS) has been reported after co-administration of injectedtriamcinolone and ritonavir. Clinical evolution is however poorly described and recommendations on how to manage this drug-drug interaction are lacking. Methods: We performed a systematic review of all reported cases of ICS exploring Pubmed, Embase, Cochrane library, and articles references. Time to Hypothalamic-Pituitary-Adrenal (HPA) axis recovery for patients with or without ritonavir interruption, was compared in a Cox model adjusted for confounding factors.
Keywords		Cushing Syndrome — Ritonavir — Triamcinolone — Injections — HIV infections
Identifiers		DOI: 10.4172/jaa.1000086
Full text		Article (Published version) (723 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Research group		Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
Citation (ISO format)		JOHN, Gregor Raphaël et al. Clinical Course and Management of Iatrogenic Cushing’s Syndrome after Co-Administration of Injected-Triamcinolone and Ritonavir: a Systematic Review. In: Journal of Antivirals and Antiretrovirals, 2013, vol. 05, n° 07. doi: 10.4172/jaa.1000086 https://archive-ouverte.unige.ch/unige:99750