UNIGE document Scientific Article
previous document  unige:99746  next document
add to browser collection
Title

Increased Cell Proliferation and Gene Expression of Genes Related to Bone Remodeling, Cell Adhesion and Collagen Metabolism in the Periodontal Ligament of Unopposed Molars in Growing Rats

Authors
Halazonetis, Thanos D
Published in Frontiers in Physiology. 2017, vol. 8, p. 75
Abstract Tooth eruption, the process by which teeth emerge from within the alveolar bone into the oral cavity, is poorly understood. The post-emergent phase of tooth eruption continues throughout life, in particular, if teeth are not opposed by antagonists. The aim of the present study was to better understand the molecular processes underlying post-emergent tooth eruption. Toward this goal, we removed the crowns of the maxillary molars on one side of the mouth of 14 young rats and examined gene expression patterns in the periodontal ligaments (PDLs) of the ipsilateral and contralateral mandibular molars, 3 and 15 days later. Nine untreated rats served as controls. Expression of six genes, Adamts18, Ostn, P4ha3, Panx3, Pth1r, and Tnmd, was upregulated in unopposed molars relative to molars with antagonists. These genes function in osteoblast differentiation and proliferation, cell adhesion and collagen metabolism. Proliferation of PDL cells also increased following loss of the antagonist teeth. Interestingly, mutations in PTH1R have been linked to defects in the post-emergent phase of tooth eruption in humans. We conclude that post-emergent eruption of unopposed teeth is associated with gene expression patterns conducive to alveolar bone formation and PDL remodeling.
Keywords Cell proliferationDental occlusionGene expressionPeriodontal ligamentTooth eruption
Identifiers
PMID: 28239357
Full text
Article (Published version) (1.7 MB) - public document Free access
Structures
Research groups Bochaton-Piallat Marie-Luce (pathologie et immunologie) (646)
Groupe Giannopoulou Ekatirini (médecine dentaire) (626)
Citation
(ISO format)
DOROTHEOU, Domna et al. Increased Cell Proliferation and Gene Expression of Genes Related to Bone Remodeling, Cell Adhesion and Collagen Metabolism in the Periodontal Ligament of Unopposed Molars in Growing Rats. In: Frontiers in Physiology, 2017, vol. 8, p. 75. https://archive-ouverte.unige.ch/unige:99746

51 hits

10 downloads

Update

Deposited on : 2017-11-28

Export document
Format :
Citation style :