The detection of microbial DNA but not cultured bacteria is associated with increased mortality in patients with suspected sepsis-a prospective multi-centre European observational study

O'Dwyer, M J; Starczewska, M H; Schrenzel, Jacques; Zacharowski, K; Ecker, D J; Sampath, R; Brealey, D; Singer, M; Libert, N; Wilks, Martin; Vincent, J-L

doi:10.1016/j.cmi.2016.11.010

Scientific article

English

The detection of microbial DNA but not cultured bacteria is associated with increased mortality in patients with suspected sepsis-a prospective multi-centre European observational study

ContributorsO'Dwyer, M J; Starczewska, M H; Schrenzel, Jacques; Zacharowski, K; Ecker, D J; Sampath, R; Brealey, D; Singer, M; Libert, N; Wilks, Martin; Vincent, J-L

Published inClinical Microbiology and Infection, vol. 23, no. 3, p. 208.e1-208.e6

Publication date2017

Abstract

Blood culture results inadequately stratify the mortality risk in critically ill patients with sepsis. We sought to establish the prognostic significance of the presence of microbial DNA in the bloodstream of patients hospitalized with suspected sepsis.

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Bacteria/isolation & purification
Bacteriological Techniques/methods
Blood/microbiology
Critical Illness
DNA, Bacterial/blood
Early Diagnosis
Europe
Female
Humans
Male
Middle Aged
Molecular Diagnostic Techniques/methods
Polymerase Chain Reaction/methods
Prognosis
Prospective Studies
Risk Assessment
Sepsis/diagnosis/mortality
Spectrometry, Mass, Electrospray Ionization/methods
Survival Analysis
Young Adult

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Génomique et microbiote (604)

Citation (ISO format)

O’DWYER, M J et al. The detection of microbial DNA but not cultured bacteria is associated with increased mortality in patients with suspected sepsis-a prospective multi-centre European observational study. In: Clinical Microbiology and Infection, 2017, vol. 23, n° 3, p. 208.e1–208.e6. doi: 10.1016/j.cmi.2016.11.010

Article (Published version)

Identifiers

PID : unige:99567
DOI : 10.1016/j.cmi.2016.11.010
PMID : 27890455

Journal ISSN1198-743X

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The detection of microbial DNA but not cultured bacteria is associated with increased mortality in patients with suspected sepsis-a prospective multi-centre European observational study

Blood culture results inadequately stratify the mortality risk in critically ill patients with sepsis. We sought to establish the prognostic significance of the presence of microbial DNA in the bloodstream of patients hospitalized with suspected sepsis.

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