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The biomarker-based diagnosis of Alzheimer's disease. 2-lessons from oncology

Gallo, Valentina
Yasui, Yutaka
Vineis, Paolo
Padovani, Alessandro
Mosimann, Urs
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Published in Neurobiology of aging. 2017, vol. 52, p. 141-152
Abstract Biomarkers for the diagnosis of Alzheimer's disease (AD) are not yet validated for use in clinical settings. We aim to provide a methodological framework for their systematic validation, by reference to that developed for oncology biomarkers. As for this discipline, the steps for the systematic validation of AD biomarkers need to target analytical validity, clinical validity, and clinical utility. However, the premises are different from oncology: the nature of disease (neurodegeneration vs. cancer), the purpose (improve diagnosis in clinically affected vs. screening preclinical individuals), and the target population (mild cognitive impairment patients referring to memory clinics vs. general population) lead to important differences, influencing both the design of validation studies and the use of selected biomarkers. This framework is applied within a wider initiative to assess the current available evidence on the clinical validity of biomarkers for AD, for the final aim to identify gaps and research priorities, and to inform coordinated research efforts boosting AD biomarkers research.
PMID: 28317645
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Research groups Démence du sujet âgé, troubles cognitifs, la symptomatologie cognitive (577)
Groupe Giannakopoulos Panteleimon (psychiatrie générale) (201)
Troubles de mémoire et maladie d'Alzeimer (935)
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BOCCARDI, Marina et al. The biomarker-based diagnosis of Alzheimer's disease. 2-lessons from oncology. In: Neurobiology of Aging, 2017, vol. 52, p. 141-152. doi: 10.1016/j.neurobiolaging.2017.01.021 https://archive-ouverte.unige.ch/unige:99473

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Deposited on : 2017-11-22

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