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A comparison of the solvation properties of 2-nitrophenyloctyl ether, nitrobenzene, and n-octanol as assessed by ion transfer experiments

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Gulaboski, R.
Bouchard, Géraldine
Caban, K.
Kretschmer, A.
Stojek, Z.
Girault, H. H.
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Published in Journal of Physical Chemistry. B, Condensed Matter, Materials, Surfaces, Interfaces and Biophysical. 2004, vol. 108, no. 14, p. 4565-4572
Abstract The lipophilicity of the anionic forms of drugs and model compounds was assessed by their transfer across (i) the water-2-nitrophenyloctyl ether (NPOE), (ii) the water-nitrobenzene (NB), and (iii) the water-n-octanol interfaces by using the three-phase electrode technique. The lipophilicities, expressed in terms of logarithm of partition coefficients, range for the studied anions from -3.46 to 0.68 (log P-A-,aq(circle minusNPOE)) for NPOE, from -3.81 to 2.62 (log P-A-,aq(circle minusNB)) for NB, and from -6.20 to -3.20 (log P-A-,aq(circle minusn-oct)) for n-octanol. Although NPOE shares with nitrobenzene the aromatic part and with n-octanol the hydrophobic carbon chain, only very weak correlation was observed between the NPOE-based-data with the n-octanol-based data, and the same is true for the correlation of the NB-based and n-octanol-based data. However, there is a strong and even linear correlation between the NPOE-based and the NB-based data
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GULABOSKI, R. et al. A comparison of the solvation properties of 2-nitrophenyloctyl ether, nitrobenzene, and n-octanol as assessed by ion transfer experiments. In: Journal of Physical Chemistry. B, Condensed Matter, Materials, Surfaces, Interfaces and Biophysical, 2004, vol. 108, n° 14, p. 4565-4572. https://archive-ouverte.unige.ch/unige:9936

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Deposited on : 2010-08-06

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