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Monoamine oxidase inhibitor properties of some benzazoles: structure-activity relationships

Grandi, Teresa
Sparatore, F.
Gnerre, Carmela
Crivori, P.
Testa, Bernard
Published in AAPS PharmSci. 1999, vol. 1, no. 4, E16
Abstract Benzazoles containing two or three nitrogen atoms were screened for their inhibitory activity toward monoamine oxidases MAO-A and MAO-B. In order to clarify the mechanism of interaction of these compounds with the enzyme, their electronic structure was calculated at the ab initio level and the influence of lipophilicity on activity was investigated. The mode of binding of benzazoles to MAO-B appears different from that of previously investigated heterocycles.
Keywords AnimalsBenzimidazoles/chemistry/*pharmacologyDrug Evaluation, PreclinicalIndazoles/chemistry/*pharmacologyMonoamine Oxidase/*metabolismMonoamine Oxidase Inhibitors/chemistry/*pharmacologyRatsStructure-Activity RelationshipTriazoles/chemistry/*pharmacology
PMID: 11741212
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GRANDI, Teresa et al. Monoamine oxidase inhibitor properties of some benzazoles: structure-activity relationships. In: AAPS PharmSci, 1999, vol. 1, n° 4, p. E16. doi: 10.1208/ps010416

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Deposited on : 2010-08-06

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