Monoamine oxidase inhibitor properties of some benzazoles: structure-activity relationships
|Published in||AAPS PharmSci. 1999, vol. 1, no. 4, p. E16|
|Abstract||Benzazoles containing two or three nitrogen atoms were screened for their inhibitory activity toward monoamine oxidases MAO-A and MAO-B. In order to clarify the mechanism of interaction of these compounds with the enzyme, their electronic structure was calculated at the ab initio level and the influence of lipophilicity on activity was investigated. The mode of binding of benzazoles to MAO-B appears different from that of previously investigated heterocycles.|
|Keywords||Animals — Benzimidazoles/chemistry/*pharmacology — Drug Evaluation, Preclinical — Indazoles/chemistry/*pharmacology — Monoamine Oxidase/*metabolism — Monoamine Oxidase Inhibitors/chemistry/*pharmacology — Rats — Structure-Activity Relationship — Triazoles/chemistry/*pharmacology|
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|GRANDI, Teresa et al. Monoamine oxidase inhibitor properties of some benzazoles: structure-activity relationships. In: AAPS PharmSci, 1999, vol. 1, n° 4, p. E16. https://archive-ouverte.unige.ch/unige:9934|