The conformation-dependent lipophilicity of morphine glucuronides as calculated from their molecular lipophilicity potential

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Title		The conformation-dependent lipophilicity of morphine glucuronides as calculated from their molecular lipophilicity potential
Authors		Gaillard, Patrick Carrupt, Pierre-Alain Testa, Bernard
Published in		Bioorganic & Medicinal Chemistry Letters. 1994, vol. 4, no. 5, p. 737-742
Abstract		A whole range of conformers of morphine-6-0-glucuronide and morphine 3-0-glucuronide were examined for their theoretical log P values using the molecular lipophilicity potential method. The results substantiate the ''chameleonic'' behavior of morphine glucuronides to exist in water as hydrophilic, extended conformers, and in lipidic media as folded, more lipophilic conformers
Identifiers		DOI: 10.1016/s0960-894x(01)80191-8
Full text		This document has no fulltext available yet, but you can contact its author by using the form below.
Citation (ISO format)		GAILLARD, Patrick, CARRUPT, Pierre-Alain, TESTA, Bernard. The conformation-dependent lipophilicity of morphine glucuronides as calculated from their molecular lipophilicity potential. In: Bioorganic & Medicinal Chemistry Letters, 1994, vol. 4, n° 5, p. 737-742. https://archive-ouverte.unige.ch/unige:9932

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