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The conformation-dependent lipophilicity of morphine glucuronides as calculated from their molecular lipophilicity potential

Authors
Gaillard, Patrick
Testa, Bernard
Published in Bioorganic & Medicinal Chemistry Letters. 1994, vol. 4, no. 5, p. 737-742
Abstract A whole range of conformers of morphine-6-0-glucuronide and morphine 3-0-glucuronide were examined for their theoretical log P values using the molecular lipophilicity potential method. The results substantiate the ''chameleonic'' behavior of morphine glucuronides to exist in water as hydrophilic, extended conformers, and in lipidic media as folded, more lipophilic conformers
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GAILLARD, Patrick, CARRUPT, Pierre-Alain, TESTA, Bernard. The conformation-dependent lipophilicity of morphine glucuronides as calculated from their molecular lipophilicity potential. In: Bioorganic & Medicinal Chemistry Letters, 1994, vol. 4, n° 5, p. 737-742. https://archive-ouverte.unige.ch/unige:9932

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Deposited on : 2010-08-06

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