The conformation-dependent lipophilicity of morphine glucuronides as calculated from their molecular lipophilicity potential

Gaillard, Patrick; Carrupt, Pierre-Alain; Testa, Bernard

doi:10.1016/s0960-894x(01)80191-8

Scientific article

English

The conformation-dependent lipophilicity of morphine glucuronides as calculated from their molecular lipophilicity potential

Contributors

Gaillard, Patrick; Carrupt, Pierre-Alain; Testa, Bernard

Published in

Bioorganic & medicinal chemistry letters, vol. 4, no. 5, p. 737-742

Publication date

1994

Abstract

A whole range of conformers of morphine-6-0-glucuronide and morphine 3-0-glucuronide were examined for their theoretical log P values using the molecular lipophilicity potential method. The results substantiate the ''chameleonic'' behavior of morphine glucuronides to exist in water as hydrophilic, extended conformers, and in lipidic media as folded, more lipophilic conformers

UNIGE affiliation entities

Not a UNIGE publication

Citation (ISO format)

GAILLARD, Patrick, CARRUPT, Pierre-Alain, TESTA, Bernard. The conformation-dependent lipophilicity of morphine glucuronides as calculated from their molecular lipophilicity potential. In: Bioorganic & medicinal chemistry letters, 1994, vol. 4, n° 5, p. 737–742. doi: 10.1016/s0960-894x(01)80191-8

Identifiers

PID : unige:9932
DOI : 10.1016/s0960-894x(01)80191-8

Journal ISSN

0960-894X

656views

0downloads

Creation

06/08/2010 10:46:45

First validation

06/08/2010 10:46:45

Update

14/03/2023 15:56:22

Status update

14/03/2023 15:56:22

Last indexation

29/10/2024 16:20:42

The conformation-dependent lipophilicity of morphine glucuronides as calculated from their molecular lipophilicity potential

Contributors

Published in

Publication date

Abstract

UNIGE affiliation entities

Citation (ISO format)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation