Scientific article
English

The conformation-dependent lipophilicity of morphine glucuronides as calculated from their molecular lipophilicity potential

Published inBioorganic & medicinal chemistry letters, vol. 4, no. 5, p. 737-742
Publication date1994
Abstract

A whole range of conformers of morphine-6-0-glucuronide and morphine 3-0-glucuronide were examined for their theoretical log P values using the molecular lipophilicity potential method. The results substantiate the ''chameleonic'' behavior of morphine glucuronides to exist in water as hydrophilic, extended conformers, and in lipidic media as folded, more lipophilic conformers

Affiliation entities Not a UNIGE publication
Citation (ISO format)
GAILLARD, Patrick, CARRUPT, Pierre-Alain, TESTA, Bernard. The conformation-dependent lipophilicity of morphine glucuronides as calculated from their molecular lipophilicity potential. In: Bioorganic & medicinal chemistry letters, 1994, vol. 4, n° 5, p. 737–742. doi: 10.1016/s0960-894x(01)80191-8
Identifiers
Journal ISSN0960-894X
616views
0downloads

Technical informations

Creation06/08/2010 10:46:45
First validation06/08/2010 10:46:45
Update time14/03/2023 15:56:22
Status update14/03/2023 15:56:22
Last indexation29/10/2024 16:20:42
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack