Synthesis, biological activity and molecular modelling of the 53-54 ketomethylene analogue of HEL(52-61)

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Title		Synthesis, biological activity and molecular modelling of the 53-54 ketomethylene analogue of HEL(52-61)
Authors		Ettouati, L. Casimir, J. R. Raynaud, I. Trescol-Biemont, M. C. Carrupt, Pierre-Alain Gerlier, D. Rabourdin-Combe, C. Testa, Bernard Paris, J. show all authors [1 - 9]
Published in		Protein and Peptide Letters. 1998, vol. 5, no. 4, p. 221-229
Abstract		The synthesis of the 53-54 ketomethylene isostere of HEL(52-61), an antigenic decapeptide, was realised by convergent Fmoc solid-phase peptide synthesis. In addition to the target peptide, an unexpected hydroxysuccinyl by-product was recovered. The two ketomethylene epimers did not exhibit any stimulating or competitive activity. Molecular modelling studies of the analogues-MHC-II I-A(k) complex suggested a departure from the canonical polyproline II conformation which could account for the absence of binding to I-A(k) molecule
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Citation (ISO format)		ETTOUATI, L. et al. Synthesis, biological activity and molecular modelling of the 53-54 ketomethylene analogue of HEL(52-61). In: Protein and Peptide Letters, 1998, vol. 5, n° 4, p. 221-229. https://archive-ouverte.unige.ch/unige:9929

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