Quantitative structure-affinity relationships of dopamine D2 receptor antagonists - a comparison between orthopramides and 6-methoxysalicylamides
|Published in||Helvetica Chimica Acta. 1991, vol. 74, no. 2, p. 241-254|
|Abstract||A large series of orthopramides (= 2-methoxybenzamides), 6-methoxysalicylamides, and 2,6-dimethoxybenzamides were examined for their affinity to the dopamine D2 receptor. The binding data were correlated with physicochemical parameters and C-13-NMR chemical shifts using the cross-validated partial least-squares method and multiple linear regression analysis. The results quantitate the influence of electronic factors and lipophilicity to D2 receptor binding. They also show that the N-[(1-ethylpyrrolidin-2-yl)methyl] and N-(1-benzylpiperidin-4-yl) side-chains affect the mode of binding of these compounds|
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|DE PAULIS, Tomas et al. Quantitative structure-affinity relationships of dopamine D2 receptor antagonists - a comparison between orthopramides and 6-methoxysalicylamides. In: Helvetica Chimica Acta, 1991, vol. 74, n° 2, p. 241-254. doi: 10.1002/hlca.19910740202 https://archive-ouverte.unige.ch/unige:9923|