UNIGE document Scientific Article
previous document  unige:99221  next document
add to browser collection

Glutamate pathways of the beta-cell and the control of insulin secretion

Published in Diabetes Research and Clinical Practice. 2017, vol. 131, p. 149-153
Abstract Pancreatic beta-cells secrete insulin in response to circulating glucose, thereby maintaining euglycemia. Inside the beta-cell, glucose is transformed into intracellular signals stimulating exocytosis. While calcium is an obligatory messenger, this ion is not sufficient to promote the full secretory response. Accordingly, glucose metabolism produces the additive factor glutamate that participates to an amplifying pathway of the calcium signal. Although intracellular glutamate potentiates insulin secretion, extracellular glutamate may activate ionotropic receptors. As a consequence of such activation, insulin exocytosis is slowed down. Therefore, for the beta-cell glutamate is a double-edged sword, an amplifying pathway and a negative feedback, illustrating the principle of homeostasis.
PMID: 28743063
Full text
Article (Published version) (554 Kb) - public document Free access
Research group Mitochondries et sécrétion d'insuline (671)
Project FNS: 31003A 146984
(ISO format)
MAECHLER, Pierre. Glutamate pathways of the beta-cell and the control of insulin secretion. In: Diabetes Research and Clinical Practice, 2017, vol. 131, p. 149-153. doi: 10.1016/j.diabres.2017.07.009 https://archive-ouverte.unige.ch/unige:99221

244 hits



Deposited on : 2017-11-17

Export document
Format :
Citation style :