Article (Published version) (841 Kb) - Limited access to UNIGE
A single-scan protocol for absolute D2/3 receptor quantification with [(123)I]IBZM SPECT.
|Published in||NeuroImage. 2017, vol. 147, p. 461-472|
|Abstract||Molecular imaging of the D2/3 receptor is widely used in neuropsychiatric research. Non-displaceable binding potential (BPND) is a very popular quantitative index, defined as the product of the receptor concentration (Bavail) and the radiotracer affinity for the receptor (1/appKd). As the appKd is influenced by parameters such as the endogenous neurotransmitter dynamics, it often constitutes a confounding factor in research studies. A simplified method for absolute quantification of both these parameters would be of great interest in this context. Here, we describe the use of a partial saturation protocol that permits to produce an in vivo Scatchard plot and thus estimate Bavail and appKd separately, through a single dynamic SPECT session. To validate this approach, a multi-injection protocol is used for the full kinetic modeling of [(123)I]IBZM using a 3-tissue compartment, 7-parameter model (3T-7k). Finally, more "classic" BPND estimation methods are also validated against the results of the 3T-7k.|
|Research groups||Abus de substances (834)|
Neuroimagerie moléculaire en psychiatrie (983)
Imagerie de la transmission dopaminergique dans les troubles addictifs (989)
|TSARTSALIS, Stergios et al. A single-scan protocol for absolute D2/3 receptor quantification with [(123)I]IBZM SPECT. In: NeuroImage, 2017, vol. 147, p. 461-472. doi: 10.1016/j.neuroimage.2016.12.050 https://archive-ouverte.unige.ch/unige:98926|