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Scientific article
English

A single-scan protocol for absolute D2/3 receptor quantification with [(123)I]IBZM SPECT

Published inNeuroImage, vol. 147, p. 461-472
Publication date2017
Abstract

Molecular imaging of the D2/3 receptor is widely used in neuropsychiatric research. Non-displaceable binding potential (BPND) is a very popular quantitative index, defined as the product of the receptor concentration (Bavail) and the radiotracer affinity for the receptor (1/appKd). As the appKd is influenced by parameters such as the endogenous neurotransmitter dynamics, it often constitutes a confounding factor in research studies. A simplified method for absolute quantification of both these parameters would be of great interest in this context. Here, we describe the use of a partial saturation protocol that permits to produce an in vivo Scatchard plot and thus estimate Bavail and appKd separately, through a single dynamic SPECT session. To validate this approach, a multi-injection protocol is used for the full kinetic modeling of [(123)I]IBZM using a 3-tissue compartment, 7-parameter model (3T-7k). Finally, more "classic" BPND estimation methods are also validated against the results of the 3T-7k.

Citation (ISO format)
TSARTSALIS, Stergios et al. A single-scan protocol for absolute D<sub>2/3</sub> receptor quantification with [<sup>(123)</sup>I]IBZM SPECT. In: NeuroImage, 2017, vol. 147, p. 461–472. doi: 10.1016/j.neuroimage.2016.12.050
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ISSN of the journal1053-8119
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Creation08/30/2017 1:14:00 PM
First validation08/30/2017 1:14:00 PM
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