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A single-scan protocol for absolute D2/3 receptor quantification with [(123)I]IBZM SPECT.

Published in NeuroImage. 2017, vol. 147, p. 461-472
Abstract Molecular imaging of the D2/3 receptor is widely used in neuropsychiatric research. Non-displaceable binding potential (BPND) is a very popular quantitative index, defined as the product of the receptor concentration (Bavail) and the radiotracer affinity for the receptor (1/appKd). As the appKd is influenced by parameters such as the endogenous neurotransmitter dynamics, it often constitutes a confounding factor in research studies. A simplified method for absolute quantification of both these parameters would be of great interest in this context. Here, we describe the use of a partial saturation protocol that permits to produce an in vivo Scatchard plot and thus estimate Bavail and appKd separately, through a single dynamic SPECT session. To validate this approach, a multi-injection protocol is used for the full kinetic modeling of [(123)I]IBZM using a 3-tissue compartment, 7-parameter model (3T-7k). Finally, more "classic" BPND estimation methods are also validated against the results of the 3T-7k.
PMID: 28011253
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Article (Published version) (841 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research groups Abus de substances (834)
Imagerie de la transmission dopaminergique dans les troubles addictifs (989)
Neuroimagerie moléculaire en psychiatrie (983)
Swiss National Science Foundation: 310030_156829
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TSARTSALIS, Stergios et al. A single-scan protocol for absolute D2/3 receptor quantification with [(123)I]IBZM SPECT. In: NeuroImage, 2017, vol. 147, p. 461-472. doi: 10.1016/j.neuroimage.2016.12.050 https://archive-ouverte.unige.ch/unige:98926

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Deposited on : 2017-11-14

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