A single-scan protocol for absolute D2/3 receptor quantification with [(123)I]IBZM SPECT

Article Article scientifique Article A single-scan protocol for absolute D2/3 receptor quantification with [(123)I]IBZM SPECT eng 2017 author Tsartsalis Stergios 0000-0002-6565-6313 782369 author Tournier Benjamin 705309 author Aoun Karl 833518 author Habiby Alaoui Sélim 823723 author Pandolfo Diego 819534 author Dimiziani Andréa 833848 author Ginovart Nathalie 0000-0003-1684-6599 637504 author Millet Philippe 0000-0002-5803-0478 668343 461-472 10.1016/j.neuroimage.2016.12.050 28011253 1053-8119 Molecular imaging of the D2/3 receptor is widely used in neuropsychiatric research. Non-displaceable binding potential (BPND) is a very popular quantitative index, defined as the product of the receptor concentration (Bavail) and the radiotracer affinity for the receptor (1/appKd). As the appKd is influenced by parameters such as the endogenous neurotransmitter dynamics, it often constitutes a confounding factor in research studies. A simplified method for absolute quantification of both these parameters would be of great interest in this context. Here, we describe the use of a partial saturation protocol that permits to produce an in vivo Scatchard plot and thus estimate Bavail and appKd separately, through a single dynamic SPECT session. To validate this approach, a multi-injection protocol is used for the full kinetic modeling of [(123)I]IBZM using a 3-tissue compartment, 7-parameter model (3T-7k). Finally, more "classic" BPND estimation methods are also validated against the results of the 3T-7k. Dewey 616.8 Dewey 616.89 Swiss National Science Foundation Studying the neurochemical determinants of antipsychotic efficacy and side effect profile: a translational dopamine D2 and serotonin 2A receptor neuroimaging approach 156829 CH Project funding 60 Département de psychiatrie 225 61 Département des neurosciences cliniques 226 false 496 Abus de substances 834 1250 Imagerie de la transmission dopaminergique dans les troubles addictifs 989 1221 Neuroimagerie moléculaire en psychiatrie 983 NeuroImage 147 93168e0b-31f8-4029-9e85-d95101e9d856 Article (Published version) Restricted 1-s2.0-S1053811916307777-main.pdf 861205 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

Title	Published in	Year	Views	Downloads

A single-scan protocol for absolute D_2/3 receptor quantification with [⁽¹²³⁾I]IBZM SPECT	NeuroImage	2017	719	6
Les récepteurs dopaminergiques D2/3 et la libération de dopamine induite par amphétamine dans les traits d'impulsivité et de recherche de nouveauté : une étude en imagerie SPECT		2016	385	9

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