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Title

Increased interleukin-27 cytokine expression in the central nervous system of multiple sclerosis patients
Authors
Lalive d'Epinay, Patrice
Kreutzfeldt, Mario
Devergne, Odile
Metz, Imke
Bruck, Wolfgang
Merkler, Doron
Pot, Caroline
Published in Journal of neuroinflammation. 2017, vol. 14, no. 1, 144
Abstract Multiple sclerosis (MS) is an autoimmune disorder characterized by chronic inflammation, demyelination, and neuronal damage. During autoimmunity, cytokines are important mediators of the inflammation. In this line, interleukin-27 (IL-27) modulates inflammation and can be produced directly at inflammatory sites such as in the joints during rheumatoid arthritis or in the central nervous system (CNS) during MS. While in animal models of MS, treatment with IL-27 decreases the disease severity, its role in humans is not clearly established and it is not known if IL-27 could be detected in the cerebrospinal fluid (CSF) of MS patients.
Identifiers
PMID: 28738904
Full text
Article (Published version) (911 Kb) - public document Free access
Structures
Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques
Research groups La Sclérose en plaques (908)
Scléroses en plaques, neuroimmunologie, encéphalite autoimmune expérimentale (843)
Citation
(ISO format) 		LALIVE D'EPINAY, Patrice et al. Increased interleukin-27 cytokine expression in the central nervous system of multiple sclerosis patients. In: Journal of Neuroinflammation, 2017, vol. 14, n° 1, p. 144. doi: 10.1186/s12974-017-0919-1 https://archive-ouverte.unige.ch/unige:98396

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Deposited on : 2017-11-01

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