Scientific article
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English

Increased interleukin-27 cytokine expression in the central nervous system of multiple sclerosis patients

Published inJournal of Neuroinflammation, vol. 14, no. 1, 144
Publication date2017
Abstract

Multiple sclerosis (MS) is an autoimmune disorder characterized by chronic inflammation, demyelination, and neuronal damage. During autoimmunity, cytokines are important mediators of the inflammation. In this line, interleukin-27 (IL-27) modulates inflammation and can be produced directly at inflammatory sites such as in the joints during rheumatoid arthritis or in the central nervous system (CNS) during MS. While in animal models of MS, treatment with IL-27 decreases the disease severity, its role in humans is not clearly established and it is not known if IL-27 could be detected in the cerebrospinal fluid (CSF) of MS patients.

Citation (ISO format)
LALIVE D’EPINAY, Patrice et al. Increased interleukin-27 cytokine expression in the central nervous system of multiple sclerosis patients. In: Journal of Neuroinflammation, 2017, vol. 14, n° 1, p. 144. doi: 10.1186/s12974-017-0919-1
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Journal ISSN1742-2094
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