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Title

SU(VAR)3-7 Links Heterochromatin and Dosage Compensation in Drosophila

Authors
Spierer, Anne
Begeot, Flora
Published in PLOS Genetics. 2008, vol. 4, no. 5, p. 13p.
Abstract In Drosophila, dosage compensation augments X chromosome-linked transcription in males relative to females. This process is achieved by the Dosage Compensation Complex (DCC), which associates specifically with the male X chromosome. We previously found that the morphology of this chromosome is sensitive to the amounts of the heterochromatin-associated protein SU(VAR)3-7. In this study, we examine the impact of change in levels of SU(VAR)3-7 on dosage compensation. We first demonstrate that the DCC makes the X chromosome a preferential target for heterochromatic markers. In addition, reduced or increased amounts of SU(VAR)3-7 result in redistribution of the DCC proteins MSL1 and MSL2, and of Histone 4 acetylation of lysine 16, indicating that a wild-type dose of SU(VAR)3-7 is required for X-restricted DCC targeting. SU(VAR)3-7 is also involved in the dosage compensated expression of the X-linked white gene. Finally, we show that absence of maternally provided SU(VAR)3-7 renders dosage compensation toxic in males, and that global amounts of heterochromatin affect viability of ectopic MSL2-expressing females. Taken together, these results bring to light a link between heterochromatin and dosage compensation.
Keywords POSITION-EFFECT VARIEGATIONMALE X-CHROMOSOMEMSL COMPLEXGENE-EXPRESSIONCHROMATIN-STRUCTUREREMODELING COMPLEXPROTEIN-1 HP1TARGET GENESSEX-LETHALROX RNAS
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SPIERER, Anne et al. SU(VAR)3-7 Links Heterochromatin and Dosage Compensation in Drosophila. In: PLOS Genetics, 2008, vol. 4, n° 5, p. 13p. https://archive-ouverte.unige.ch/unige:9831

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Deposited on : 2010-08-03

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