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The contribution of autophagy to the expression of HLA Class I molecules focusing on HLA-B*27:05

ContributorsGangath, Gracia
Master program titleMaster Biologie moléculaire ; Orientation Immunologie
Defense date2017
Abstract

Commonly referred as autophagy, macroautophagy is one of the major degradative pathways in eukaryotic cells. During macroautophagy, cytosolic material is engulfed in the autophagosome, a double-membrane-bound vesicle. The autophagosome fuses with endo-lysosomal vesicles, leading to degradation and recycling of the sequestered substrates.Autophagy has been recently shown to play a role in the innate and adaptive immune responses, by acting at multiple and diverse levels. In particular, our group has recently shown that autophagy promotes MHC Class I internalization and degradation in murine dendritic Cells (DCs). Human Leukocyte Antigen-B27 (HLA-B2) is strongly associated with the onset of ankylosing spondylitis, an inflammatory rheumathological disease. In parallel, it was shown that autophagy is up regulated in patients with ankylosing spondylitis. Our work will analyse the contribution of autophagy in the expression and degradation of human MHC Class I with a special focus on HLA-B*27:05.

eng
Keywords
  • Autophagy
  • MHC Class I
  • HLA-B*27:05
Citation (ISO format)
GANGATH, Gracia. The contribution of autophagy to the expression of HLA Class I molecules focusing on HLA-B*27:05. 2017.
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Master thesis
accessLevelRestricted
Identifiers
  • PID : unige:97441
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Technical informations

Creation10/05/2017 11:05:00 AM
First validation10/05/2017 11:05:00 AM
Update time03/15/2023 2:06:32 AM
Status update03/15/2023 2:06:32 AM
Last indexation01/29/2024 9:12:21 PM
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