The contribution of autophagy to the expression of HLA Class I molecules focusing on HLA-B*27:05

Diplôme Master The contribution of autophagy to the expression of HLA Class I molecules focusing on HLA-B*27:05 eng 2017 author Gangath Gracia 787323 director Gannagé Monique 812150 Commonly referred as autophagy, macroautophagy is one of the major degradative pathways in eukaryotic cells. During macroautophagy, cytosolic material is engulfed in the autophagosome, a double-membrane-bound vesicle. The autophagosome fuses with endo-lysosomal vesicles, leading to degradation and recycling of the sequestered substrates.Autophagy has been recently shown to play a role in the innate and adaptive immune responses, by acting at multiple and diverse levels. In particular, our group has recently shown that autophagy promotes MHC Class I internalization and degradation in murine dendritic Cells (DCs). Human Leukocyte Antigen-B27 (HLA-B2) is strongly associated with the onset of ankylosing spondylitis, an inflammatory rheumathological disease. In parallel, it was shown that autophagy is up regulated in patients with ankylosing spondylitis. Our work will analyse the contribution of autophagy in the expression and degradation of human MHC Class I with a special focus on HLA-B*27:05. Autophagy MHC Class I HLA-B*27:05 Dewey 570 Dewey 616.07 Master Biologie moléculaire ; Orientation Immunologie 43 Département de biologie moléculaire 161 137 Département de pathologie et immunologie 21F false 563 Pathologie et immunologie 906 23fd5bbd-1534-4418-a2f3-c6309bacb24f Master thesis Restricted thèse G.G 28.9.17.pdf 8839341 application/pdf restrictedAccess Faculté des sciences / Section de biologie / Département de biologie moléculaire Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

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The contribution of autophagy to the expression of HLA Class I molecules focusing on HLA-B*27:05				2017	201	4

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Gangath, Gracia