Despite the great satisfaction they can find in their work, healthcare professionals are particularly at risk of various physical and psychological health problems, including back pain, depression, suicide, and burnout. While the causes of the health problems of healthcare professionals are multifactorial, one cause lies in the emotional burden associated with providing healthcare. Regret is a normal and frequent emotion, related to decision making, and associated both with positive outcomes, such as better learning, and negative outcomes such as sleep problems. This privat-docent thesis explores and supports various aspects of a theoretical framework on the causes and consequences of regret and regret coping.